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dc.contributor.authorKobauri, Sophio
dc.contributor.authorOtinashvili, Giuli
dc.contributor.authorKantaria, Tengiz
dc.contributor.authorTugushi, David
dc.contributor.authorKharadze, Darejan
dc.contributor.authorKutsiava, Nazi
dc.contributor.authorPuiggalí Bellalta, Jordi
dc.contributor.authorKatsarava, Ramaz
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2019-04-03T17:44:17Z
dc.date.available2019-11-08T01:26:00Z
dc.date.issued2018-11-08
dc.identifier.citationKobauri, S. [et al.]. New amino acid based biodegradable poly(ester amide)s via bis-azlactone chemistry. "Journal of macromolecular science. Part A, pure and applied chemistry", 8 Novembre 2018, vol. 55, núm. 10, p. 1-29.
dc.identifier.issn1060-1325
dc.identifier.urihttp://hdl.handle.net/2117/131232
dc.description.abstractThree new classes of the amino acid based biodegradable (AABB) polymers were synthesized via step growth polymerization of bis-azlactones and amino acid based diamine-diesters with activated fatty diester and alkylenediamine: a) poly(ester amide)s (PEAs) were obtained by polymerization of bis-azlactones with diamine-diesters, b) hydrophobically modified co-poly(ester amide)s (co-PEAs) were synthesized by copolymerization of activated fatty diacid diester and bis-azlactones with diamine-diesters, and c) poly(ester amide-co-amide)s (PEA-co-PAs) were obtained by copolymerization of alkylene diamine and diamine-diesters with bis-azlactones. The new poly(ester amide)s showed relatively low-molecular-weights (Mw within 2,800–19,600¿Da, GPC in DMF), whereas the new co-poly(ester amide)s and poly(ester amide-co-amide)s exhibited high-molecular-weights (Mw within 40–100¿kDa) leading to good mechanical properties. Incorporation of the bis-azlactone fragments into the poly(ester amide)s backbone increased hydrophobicity and thermal stability, whereas incorporation of diamine-diester units into the backbone of the bis-azlactone based polyamides rendered them biodegradable. Synthesized AABB polymers are potential candidates for constructing resorbable surgical and pharmaceutical devices.
dc.format.extent29 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshPolymers
dc.subject.lcshAmino acids
dc.subject.otherbis-azlactones
dc.subject.othera-amino acids
dc.subject.otherdiamine-diesters
dc.subject.otherbiodegradable polymers
dc.subject.otherpoly(ester amide)s
dc.subject.otherco-poly(ester amide)s
dc.subject.otherpoly(ester amides-co-amide)
dc.subject.othersynthesis
dc.subject.otherhydrophobicity
dc.subject.otherthermal properties
dc.subject.otherin vitro biodegradation
dc.titleNew amino acid based biodegradable poly(ester amide)s via bis-azlactone chemistry
dc.typeArticle
dc.subject.lemacAminoàcids
dc.subject.lemacPolímers
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.identifier.doi10.1080/10601325.2018.1513776
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.tandfonline.com/doi/abs/10.1080/10601325.2018.1513776
dc.rights.accessOpen Access
local.identifier.drac23554144
dc.description.versionPostprint (published version)
local.citation.authorKobauri, S.; Otinashvili, G.; Kantaria, T.; Tugushi, D.; Kharadze, D.; Kutsiava, N.; Puiggali, J.; Katsarava, R.
local.citation.publicationNameJournal of macromolecular science. Part A, pure and applied chemistry
local.citation.volume55
local.citation.number10
local.citation.startingPage1
local.citation.endingPage29


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain