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dc.contributor.authorEchebarría Domínguez, Blas
dc.contributor.authorKarma, Alain
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.identifier.citationEchebarria, B.; Karma, A. Spatiotemporal control of cardiac alternans. "Chaos : an interdisciplinary journal of nonlinear science", 2002, vol. 12, núm. 3, p. 923-930.
dc.description.abstractElectrical alternans are believed to be linked to the onset of life-threatening ventricular arrhythmias and sudden cardiac death. Recent studies have shown that alternans can be suppressed temporally by dynamic feedback control of the pacing interval. Here we investigate theoretically whether control can suppress alternans both temporally and spatially in homogeneous tissue paced at a single site. We first carry out ionic model simulations in a one-dimensional cable geometry which show that control is only effective up to a maximum cable length that decreases sharply away from the alternans bifurcation point. We then explain this finding by a linear stability analysis of an amplitude equation that describes the spatiotemporal evolution of alternans. This analysis reveals that control failure above a critical cable length is caused by the formation of standing wave patterns of alternans that are eigenfunctions of a forced Helmholtz equation, and therefore remarkably analogous to sound harmonics in an open pipe. We discuss the implications of these results for using control to suppress alternans in the human ventricles as well as to probe fundamental aspects of alternans morphogenesis.
dc.format.extent8 p.
dc.publisherInstitute of Physics (IOP)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.subjectÀrees temàtiques de la UPC::Física
dc.titleSpatiotemporal control of cardiac alternans
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - publisher's policy
dc.description.versionPostprint (published version)
upcommons.citation.authorEchebarria, B.; Karma, A.
upcommons.citation.publicationNameChaos : an interdisciplinary journal of nonlinear science

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