Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3
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hdl:2117/130953
Tipus de documentArticle
Data publicació2018-11-28
EditorMultidisciplinary Digital Publishing Institute (MDPI)
Condicions d'accésAccés obert
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Abstract
In this work, we report the design and fabrication of a dual-function integrated system to monitor, in real time, the release of previously loaded 2-methyl-1,4-naphthoquinone (MeNQ), also named vitamin K3. The newly developed system consists of poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles, which were embedded into a poly-¿-glutamic acid (¿-PGA) biohydrogel during the gelling reaction between the biopolymer chains and the cross-linker, cystamine. After this, agglomerates of PEDOT nanoparticles homogeneously dispersed inside the
biohydrogel were used as polymerization nuclei for the in situ anodic synthesis of
poly(hydroxymethyl-3,4-ethylenedioxythiophene) in aqueous solution. After characterization of the resulting flexible electrode composites, their ability to load and release MeNQ was proven and monitored. Specifically, loaded MeNQ molecules, which organized in shells around PEDOT nanoparticles agglomerates when the drug was simply added to the initial gelling solution, were progressively released to a physiological medium. The latter process was successfully monitored using an electrode composite through differential pulse voltammetry. The fabrication of electroactive flexible biohydrogels for real-time release monitoring opens new opportunities for theranostic therapeutic approaches.
CitacióMolina, B.G. [et al.]. Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3. "Gels", 28 Novembre 2018, vol. 4, núm. 4, p. 1-14.
ISSN2310-2861
Versió de l'editorhttps://www.mdpi.com/2310-2861/4/4/86
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