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dc.contributor.authorMolina Rodriguez, Vicente
dc.contributor.authorBachiller Matarranz, Alejandro
dc.contributor.authorLuis García, Rodrigo de
dc.contributor.authorLubeiro Juárez, Alba
dc.contributor.authorPoza Crespo, Jesús
dc.contributor.authorHornero Sánchez, Roberto
dc.contributor.authorAlonso López, Joan Francesc
dc.contributor.authorMañanas Villanueva, Miguel Ángel
dc.contributor.authorMarques, Patricia
dc.contributor.authorRomero Lafuente, Sergio
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.identifier.citationMolina, V. [et al.]. Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity. "European archives of psychiatry and clinical neuroscience", 2 Febrer 2018, p. 1-22.
dc.description.abstractBackground The study of cerebral underpinnings of schizophrenia may benefit from the high temporal resolution of electromagnetic techniques, but its spatial resolution is low. However, source imaging approaches such as low-resolution brain electromagnetic tomography (LORETA) allow for an acceptable compromise between spatial and temporal resolutions. Methods We combined LORETA with 32 channels and 3-Tesla diffusion magnetic resonance (Dmr) to study cerebral dysfunction in 38 schizophrenia patients (17 first episodes, FE), compared to 53 healthy controls. The EEG was acquired with subjects performing an odd-ball task. Analyses included an adaptive window of interest to take into account the interindividual variability of P300 latency. We compared source activation patters to distractor (P3a) and target (P3b) tones within- and between-groups. Results Patients showed a reduced activation in anterior cingulate and lateral and medial prefrontal cortices, as well as inferior/orbital frontal regions. This was also found in the FE patients alone. The activation was directly related to IQ in the patients and controls and to working memory performance in controls. Symptoms were unrelated to source activation. Fractional anisotropy in the tracts connecting lateral prefrontal and anterior cingulate regions predicted source activation in these regions in the patients. Conclusions These results replicate the source activation deficit found in a previous study with smaller sample size and a lower number of sensors and suggest an association between structural connectivity deficits and functional alterations.
dc.format.extent22 p.
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina
dc.subject.lcshMagnetic resonance imaging
dc.subject.otherDiffusion tensor
dc.subject.otherAnterior cingulate
dc.titleTopography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
dc.subject.lemacImatgeria per ressonància magnètica
dc.subject.lemacEsquizofrènia -- Diagnòstic
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOART - BIOsignal Analysis for Rehabilitation and Therapy
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
local.citation.authorMolina, V.; Bachiller, A.; Luis, R. de; Lubeiro, A.; Poza, J.; Hornero, R.; Alonso, J.F.; Mañanas, M.A.; Marques, P.; Romero, S.
local.citation.publicationNameEuropean archives of psychiatry and clinical neuroscience

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