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dc.contributor.authorSrinivasan, Sundaramoorthy
dc.contributor.authorGuixà González, Ramon
dc.contributor.authorCordomí, Arnau
dc.contributor.authorGarriga Solé, Pere
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2019-03-26T12:02:59Z
dc.date.issued2019-07
dc.identifier.citationSrinivasan, S. [et al.]. Ligand binding mechanisms in human cone visual pigments. "Trends in biochemical sciences", Juliol 2019, vol. 44, no 7, p. 629-639.
dc.identifier.issn0968-0004
dc.identifier.urihttp://hdl.handle.net/2117/130855
dc.description.abstractVertebrate vision starts with light absorption by visual pigments in rod and cone photoreceptor cells of the retina. Rhodopsin, in rod cells, responds to dim light, whereas three types of cone opsins (red, green, and blue) function under bright light and mediate color vision. Cone opsins regenerate with retinal much faster than rhodopsin, but the molecular mechanism of regeneration is still unclear. Recent advances in the area pinpoint transient intermediate opsin conformations, and a possible secondary retinal-binding site, as determinant factors for regeneration. In this Review, we compile previous and recent findings to discuss possible mechanisms of ligand entry in cone opsins, involving a secondary binding site, which may have relevant functional and evolutionary implications
dc.format.extent11 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la visió::Biologia ocular
dc.subject.lcshG proteins -- Receptors
dc.subject.lcshLigands (Biochemistry)
dc.subject.lcshColor vision
dc.subject.otherVision
dc.subject.otherOpsin
dc.subject.otherRetinoids
dc.subject.otherLigand binding site
dc.subject.otherChromophore regeneration
dc.subject.otherG proteincoupled receptor
dc.subject.otherAllostery
dc.subject.otherColor blindness
dc.titleLigand binding mechanisms in human cone visual pigments
dc.typeArticle
dc.subject.lemacProteïnes G -- Receptors
dc.subject.lemacLligands (Bioquímica)
dc.subject.lemacSentit del color
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.1016/j.tibs.2019.02.001
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0968000419300246
dc.rights.accessRestricted access - publisher's policy
drac.iddocument23997512
dc.description.versionPostprint (author's final draft)
dc.relation.projectidinfo:eu-repo/grantAgreement/MICINN/6PN/SAF2011-30216-C02-01
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/212287/EU/REDOX PHENOMENA CONTROLLING SYSTEMS/RECOSY
dc.date.lift2020-03-07
upcommons.citation.authorSrinivasan, S.; Guixà, R.; Cordomí, A.; Garriga, P.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameTrends in biochemical sciences
upcommons.citation.volume44
upcommons.citation.number7
upcommons.citation.startingPage629
upcommons.citation.endingPage639
local.requestitem.embargadtrue


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Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain