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dc.contributor.authorPeñaranda Ayllón, Angelina
dc.contributor.authorEchebarría Domínguez, Blas
dc.contributor.authorÁlvarez Lacalle, Enrique
dc.contributor.authorRodríguez Cantalapiedra, Inma
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.identifier.citationPeñaranda, A. [et al.]. Effects of small conductance calcium activated potassium channels in atrial myocytes. A: Computers in Cardiology. "Computing in Cardilogy 2017 Vol. 44". Los Alamitos (California): IEEE Computer Society Conference Publishing Services (CPS), 2017, p. 1-4.
dc.description.abstractAmong the different potassium channels present in cardiac myocytes, the small conductance Ca2+ activated potassium channels (SK channels) are particular because they are affected by changes in intracellular calcium. The functional role of these channels in cardiac electrophysiology is still under intense debate. While they do not seem to play an important role in healthy hearts – their associated current, IKCa, is smaller than other potassium currents -, there is increasing evidence that they may become relevant under pathological conditions. In fact, both pro- and anti-arrhythmic effects have been assigned to these channels, depending on the clinical situation. In this work, we have incorporated the current through SK channels, IKCa, into an electrophysiological ionic model of human atria myocyte. This allows us to evaluate changes in the action potential under different parameters affecting the kinetics of these channels. We observe a large dependence of the action potential duration with the conductance and gate dynamics of the channel. The dependence of SK channels with changes in intracellular calcium dynamics helps decreasing the proarrhythmic effect of spontaneous calcium release events
dc.format.extent4 p.
dc.publisherIEEE Computer Society Conference Publishing Services (CPS)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Anatomia i fisiologia humana
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshAtrial fibrillation
dc.titleEffects of small conductance calcium activated potassium channels in atrial myocytes
dc.typeConference lecture
dc.subject.lemacArítmies auriculars
dc.contributor.groupUniversitat Politècnica de Catalunya. ANCORA - Anàlisi i control del ritme cardíac
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
dc.contributor.groupUniversitat Politècnica de Catalunya. GICITED - Grup Interdiciplinari de Ciència i Tecnologia en l'Edificació
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
dc.description.versionPostprint (published version)
local.citation.authorPeñaranda, A.; Echebarria, B.; Alvarez-Lacalle, E.; Rodriguez Cantalapiedra, I.
local.citation.contributorComputers in Cardiology
local.citation.pubplaceLos Alamitos (California)
local.citation.publicationNameComputing in Cardilogy 2017 Vol. 44

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