The unavoidable deterioration of the built urban front in the cities has been increasingly generating a huge environmental impact. From this perspective, it is necessary to develop systematized methods that facilitate strategic maintenance of the facades and which study the variables that can potentially play a significant role in the damage occurrence. Therefore it is convenient to implement analytical methodologies to the decision making process on conservation and sustainability of the built urban front with a macro-scale approach. The BRAIN platform (Building Research Analysis and Information Network) is a Multi-scale Predictive System of the Degradation of the Urban Front. By means of periodic inspections, BRAIN allows analyses of damage progression and prediction of the future affectation, based on survival/reliability statistical models. The aim of this paper is to introduce a preliminary study on the implementation of the Urban Laboratory in the city of Brno, Czech Republic. Results of this primary approach have been displayed and discussed.