Chiral magnetic-nanobiofluids for rapid electrochemical screening of enantiomers at a magneto nanocomposite graphene-paste electrode
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hdl:2117/129164
Tipus de documentArticle
Data publicació2018-05
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Abstract
The development of highly sensitive and selective enantiomeric platforms towards the rapid screening of active pharmaceutical ingredients (APIs) is nowadays a crucial challenge in several fields related to pharmacology, biomedicine, biotechnology and (bio)sensors. Herein, it is presented a novel, facile and generic methodology focused on exploiting the synergistically and electrocatalytic properties of chiral magnetic-nanobiofluids (mNBFs) with electrochemical enantiobiosensing at a magneto nanocomposite graphene paste electrode (mNC–GPE). The feasibility of this approach has been validated by chirally recognizing tryptophan (TRP) enantiomers as a proof-of-concept. For this aim, a specific chiral mNBF based on an aqueous dispersion of cobalt ferrite loaded with gold nanoparticles carrying a thiolated ß-cyclodextrin (ß–CD-SH/Au/CoFe2O4–NPs) has been synthesized and used towards the supramolecular discrimination of TRP enantiomers at an advanced graphenepaste transducer via cyclic voltammetry. This strategy, which is the first demonstration of applicability of chiral mNBFs for electrochemical enantiorecognition, opens up new approaches into enantio(bio)sensing
CitacióMuñoz, J. [et al.]. Chiral magnetic-nanobiofluids for rapid electrochemical screening of enantiomers at a magneto nanocomposite graphene-paste electrode. "Biosensors and bioelectronics", Maig 2018, vol. 105, p. 95-102.
ISSN0956-5663
Versió de l'editorhttps://www.sciencedirect.com/science/article/pii/S0956566318300319
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