Recurrent inhibition in the cerebral cortex
10.1016/j.neulet.2018.12.014
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/127960
Tipus de documentArticle
Data publicació2019-03-23
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Neuronal activity can be modulated by endogenous control mechanisms that either facilitate or suppress it. With this idea in mind, we attempted to evaluate and correlate spinal neuronal activity with the amplitude of corticogram (ECoG) event related potentials (ERP) in the presence of nociceptive stimulation in rats. We evaluated the ERP in response to noxious stimuli, endogenous analgesic actions, different frequencies, and heterotopic nociceptive stimulation, as well as in conjunction with recordings from neurons in the spinal cord that are activated by noxious stimuli. Computational tasks enabled us to establish correlations between the amplitude of ERP and neuronal firing of cells in the spinal dorsal horn.
Our results show that the ERP amplitude could be modified by previous activity in the cerebral cortex, but the activity in the spinal cord did not change. Previous activity could originate spontaneously or could be driven by sensory stimulation.
A recurrent inhibitory cortical action is proposed that could explain the suppression of pain perception during electrical or magnetic transcranial stimulation, as well as during heterotopic stimulation.
This study aims to uncover a local recurrent inhibitory cortical action that could modify the sensory information.
CitacióBéjar, J. [et al.]. Recurrent inhibition in the cerebral cortex. "Neuroscience letters", 23 Març 2019, vol. 696, p. 20-27.
ISSN0304-3940
Versió de l'editorhttps://www.sciencedirect.com/science/article/abs/pii/S0304394018308590
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
Neuroscience le ... in the cerebral cortex.pdf | 1,694Mb | Visualitza/Obre |