Supernormal conduction in cardiac tissue promotes concordant alternans and action potential bunching

View/Open
Cita com:
hdl:2117/12622
Document typeArticle
Defense date2011-04-04
Rights accessOpen Access
Abstract
Supernormal conduction (SNC) in excitable cardiac tissue refers to an increase of pulse (or action potential)
velocity with decreasing distance to the preceding pulse. Here we employ a simple ionic model to study the effect
of SNC on the propagation of action potentials (APs) and the phenomenology of alternans in excitable cardiac
tissue. We use bifurcation analysis and simulations to study attraction between propagating APs caused by SNC
that leads to AP pairs and bunching. It is shown that SNC stabilizes concordant alternans in arbitrarily long paced
one-dimensional cables. As a consequence, spiral waves in two-dimensional tissue simulations exhibit straight
nodal lines for SNC in contrast to spiraling ones in the case of normal conduction
CitationEchebarria, B. [et al.]. Supernormal conduction in cardiac tissue promotes concordant alternans and action potential bunching. "Physical review E: statistical, nonlinear, and soft matter physics", 04 Abril 2011, vol. 83, núm. 4, p. 1-4.
ISSN1539-3755
Publisher versionhttp://link.aps.org/doi/10.1103/PhysRevE.83.040902
Files | Description | Size | Format | View |
---|---|---|---|---|
echevarria_Physical_E_2011.pdf | 539,4Kb | View/Open |
Except where otherwise noted, content on this work
is licensed under a Creative Commons license
:
Attribution-NonCommercial-NoDerivs 3.0 Spain