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Properties of Omp2a-based supported lipid bilayers: comparison with polymeric bioinspired membranes
dc.contributor.author | Puiggalí Jou, Anna |
dc.contributor.author | Pawlowski, Jan |
dc.contributor.author | Valle Mendoza, Luis Javier del |
dc.contributor.author | Michaux, Catherine Anne Gisèle |
dc.contributor.author | Perpète, Eric A. |
dc.contributor.author | Sek, Slawomir |
dc.contributor.author | Alemán Llansó, Carlos |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2018-12-19T07:27:40Z |
dc.date.available | 2018-12-19T07:27:40Z |
dc.date.issued | 2018-08-01 |
dc.identifier.citation | Puiggali, A., Pawlowski, J., del Valle, LJ., Michaux, Catherine Anne Gisèle, Perpète, Eric A., Sek, S., Aleman, C. Properties of Omp2a-based supported lipid bilayers: comparison with polymeric bioinspired membranes. "ACS omega", 1 Agost 2018, vol. 3, núm. 8, p. 9003-9019. |
dc.identifier.issn | 2470-1343 |
dc.identifier.uri | http://hdl.handle.net/2117/125960 |
dc.description.abstract | Omp2a ß-barrel outer membrane protein has been reconstituted into supported lipid bilayers (SLBs) to compare the nanomechanical properties (elastic modulus, adhesion forces, and deformation) and functionality of the resulting bioinspired system with those of Omp2a-based polymeric nanomembranes (NMs). Protein reconstitution into lipid bilayers has been performed using different strategies, the most successful one consisting of a detergent-mediated process into preformed liposomes. The elastic modulus obtained for the lipid bilayer and Omp2a are ~19 and 10.5 ± 1.7 MPa, respectively. Accordingly, the protein is softer than the lipid bilayer, whereas the latter exhibits less mechanical strength than polymeric NMs. Besides, the function of Omp2a in the SLB is similar to that observed for Omp2a-based polymeric NMs. Results open the door to hybrid bioinspired substrates based on the integration of Omp2a-proteoliposomes and nanoperforated polymeric freestanding NMs. |
dc.format.extent | 17 p. |
dc.language.iso | eng |
dc.publisher | American Chemical Society (ACS) |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Proteins |
dc.subject.lcsh | Membranes (Technology) |
dc.subject.lcsh | Biomedical materials |
dc.subject.other | Biological membrane |
dc.subject.other | Mechanical properties |
dc.subject.other | Nanostructures |
dc.subject.other | Proteins |
dc.title | Properties of Omp2a-based supported lipid bilayers: comparison with polymeric bioinspired membranes |
dc.type | Article |
dc.subject.lemac | Proteïnes |
dc.subject.lemac | Membranes (Tecnologia) |
dc.subject.lemac | Materials biomèdics |
dc.contributor.group | Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies |
dc.contributor.group | Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
dc.identifier.doi | 10.1021/acsomega.8b00913 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://pubs.acs.org/doi/abs/10.1021/acsomega.8b00913 |
dc.rights.access | Open Access |
local.identifier.drac | 23504671 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Puiggali, A.; Pawlowski, J.; del Valle, LJ.; Michaux, Catherine Anne Gisèle; Perpète, Eric A.; Sek, S.; Aleman, C. |
local.citation.publicationName | ACS omega |
local.citation.volume | 3 |
local.citation.number | 8 |
local.citation.startingPage | 9003 |
local.citation.endingPage | 9019 |
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