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dc.contributor.authorValenti, Sofia
dc.contributor.authorRomanini, Michela
dc.contributor.authorFranco García, María Lourdes
dc.contributor.authorPuiggalí Bellalta, Jordi
dc.contributor.authorTamarit Mur, José Luis
dc.contributor.authorMacovez, Roberto
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2018-12-12T15:54:08Z
dc.date.available2019-10-23T00:25:55Z
dc.date.issued2018-10-23
dc.identifier.citationValenti, S., Romanini, M., Franco, L., Puiggali, J., Tamarit, J. Ll., Macovez, R. Tuning the Kinetic Stability of the Amorphous Phase of the Chloramphenicol Antibiotic. "Molecular pharmaceutics", 23 Octubre 2018, vol. 15, núm. 12, p. 5615-5624.
dc.identifier.issn1543-8384
dc.identifier.urihttp://hdl.handle.net/2117/125730
dc.description.abstractWe employ broadband dielectric spectroscopy to study the relaxation dynamics and crystallization kinetics of a broad-spectrum antibiotic, chloramphenicol, in its supercooled liquid form. Two dynamic processes are observed: the structural a relaxation, which becomes kinetically frozen at Tg = 302 ± 1 K, and an intramolecular secondary relaxation. Under isothermal conditions, the supercooled drug displays interconversion between different isomers, followed by recrystallization. Recrystallization follows the Avrami law with Avrami exponent n = 1.3 ± 0.1, consistent with a one dimensional growth of crystalline platelets, as observed by electron microscopy. Exposure to humid atmosphere and subsequent heating to high temperature is found to degrade the compound. The partially degraded sample displays a much lower tendency to crystallize, likely because the presence of the degradation products results in spatial frustration. This sample exhibits enhanced conductivity and an additional relaxation, intermediate to the ones observed in the pure sample, which likely corresponds to the noncooperative dynamics of the main degradation product. We find that dispersing the antibiotic in polylactic acid results in an amorphous sample which does not crystallize at room temperature for relatively long times.
dc.format.extent10 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshCrystallization
dc.subject.otherSupercooled drug
dc.subject.othermolecular mobility
dc.subject.othercrystallization kinetics
dc.subject.otherchemical degradation
dc.subject.otherdielectric spectroscopy
dc.subject.otherpolylactic acid
dc.titleTuning the Kinetic Stability of the Amorphous Phase of the Chloramphenicol Antibiotic
dc.typeArticle
dc.subject.lemacCristal·lització
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.identifier.doi10.1021/acs.molpharmaceut.8b00786
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00786
dc.rights.accessOpen Access
local.identifier.drac23536315
dc.description.versionPostprint (published version)
local.citation.authorValenti, S.; Romanini, M.; Franco, L.; Puiggali, J.; Tamarit, J. Ll.; Macovez, R.
local.citation.publicationNameMolecular pharmaceutics
local.citation.volume15
local.citation.number12
local.citation.startingPage5615
local.citation.endingPage5624


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain