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Tuning the Kinetic Stability of the Amorphous Phase of the Chloramphenicol Antibiotic
dc.contributor.author | Valenti, Sofia |
dc.contributor.author | Romanini, Michela |
dc.contributor.author | Franco García, María Lourdes |
dc.contributor.author | Puiggalí Bellalta, Jordi |
dc.contributor.author | Tamarit Mur, José Luis |
dc.contributor.author | Macovez, Roberto |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2018-12-12T15:54:08Z |
dc.date.available | 2019-10-23T00:25:55Z |
dc.date.issued | 2018-10-23 |
dc.identifier.citation | Valenti, S., Romanini, M., Franco, L., Puiggali, J., Tamarit, J. Ll., Macovez, R. Tuning the Kinetic Stability of the Amorphous Phase of the Chloramphenicol Antibiotic. "Molecular pharmaceutics", 23 Octubre 2018, vol. 15, núm. 12, p. 5615-5624. |
dc.identifier.issn | 1543-8384 |
dc.identifier.uri | http://hdl.handle.net/2117/125730 |
dc.description.abstract | We employ broadband dielectric spectroscopy to study the relaxation dynamics and crystallization kinetics of a broad-spectrum antibiotic, chloramphenicol, in its supercooled liquid form. Two dynamic processes are observed: the structural a relaxation, which becomes kinetically frozen at Tg = 302 ± 1 K, and an intramolecular secondary relaxation. Under isothermal conditions, the supercooled drug displays interconversion between different isomers, followed by recrystallization. Recrystallization follows the Avrami law with Avrami exponent n = 1.3 ± 0.1, consistent with a one dimensional growth of crystalline platelets, as observed by electron microscopy. Exposure to humid atmosphere and subsequent heating to high temperature is found to degrade the compound. The partially degraded sample displays a much lower tendency to crystallize, likely because the presence of the degradation products results in spatial frustration. This sample exhibits enhanced conductivity and an additional relaxation, intermediate to the ones observed in the pure sample, which likely corresponds to the noncooperative dynamics of the main degradation product. We find that dispersing the antibiotic in polylactic acid results in an amorphous sample which does not crystallize at room temperature for relatively long times. |
dc.format.extent | 10 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject | Àrees temàtiques de la UPC::Física |
dc.subject.lcsh | Crystallization |
dc.subject.other | Supercooled drug |
dc.subject.other | molecular mobility |
dc.subject.other | crystallization kinetics |
dc.subject.other | chemical degradation |
dc.subject.other | dielectric spectroscopy |
dc.subject.other | polylactic acid |
dc.title | Tuning the Kinetic Stability of the Amorphous Phase of the Chloramphenicol Antibiotic |
dc.type | Article |
dc.subject.lemac | Cristal·lització |
dc.contributor.group | Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials |
dc.contributor.group | Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
dc.identifier.doi | 10.1021/acs.molpharmaceut.8b00786 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00786 |
dc.rights.access | Open Access |
local.identifier.drac | 23536315 |
dc.description.version | Postprint (published version) |
local.citation.author | Valenti, S.; Romanini, M.; Franco, L.; Puiggali, J.; Tamarit, J. Ll.; Macovez, R. |
local.citation.publicationName | Molecular pharmaceutics |
local.citation.volume | 15 |
local.citation.number | 12 |
local.citation.startingPage | 5615 |
local.citation.endingPage | 5624 |
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