Plasma polymerized bioceramics for drug delivery: Do surface changes alter biological behaviour?
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10.1016/j.eurpolymj.2018.07.016
Inclou dades d'ús des de 2022
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hdl:2117/125163
Tipus de documentArticle
Data publicació2018-10-01
EditorElsevier
Condicions d'accésAccés obert
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
One of the treatments for recurrent or complicated osteomyelitis is by local antibiotherapy mediated by suitable bone grafts. ß–Tricalcium Phosphate (ß–TCP) bioceramic is a resorbable bone graft. Its microporosity allows for incorporation of drugs, but a too fast release is often obtained. Complex strategies have been explored to obtain controlled drug release. In this work, plasma polymerization of a biocompatible polymer was investigated on ß-TCP. Polyethyleneglycol (PEG)-like polymer coatings of different thickness were deposited on microporous ß-TCP loaded with antibiotics. A highly hydrophobic surface was obtained despite the hydrophilicity of the PEG-like layer produced, which was associated to the roughness of the ß-TCP substrate. The bioceramics nevertheless retained their suitable biological behavior with regard to human osteoblast cells. The microbiological activity of the antibiotics was preserved, and the coatings reduced the total amount of drug released as a function of the increasing plasma treatment time.
CitacióKhurana, K., Müller, F., Jacobs, K., Canal, C., Ginebra, M.P. Plasma polymerized bioceramics for drug delivery: Do surface changes alter biological behaviour?. "European polymer journal", 1 Octubre 2018, vol. 107, p. 25-33.
ISSN0014-3057
Versió de l'editorhttps://www.sciencedirect.com/science/article/pii/S0014305718304130
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Khurana EPolymerJ Postprint 2018.pdf | 15,84Mb | Visualitza/Obre |