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dc.contributor.authorStefanov, Ivaylo
dc.contributor.authorHinojosa Caballero, Dolores
dc.contributor.authorMaspoch, Santiago
dc.contributor.authorHoyo Pérez, Javier
dc.contributor.authorTzanov, Tzanko
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2018-11-14T10:58:28Z
dc.date.available2019-10-26T00:26:12Z
dc.date.issued2018-10-26
dc.identifier.citationStefanov, I., Hinojosa, D., Maspoch, S., Hoyo, J., Tzanov, T. Enzymatic synthesis of a thiolated chitosan-based wound dressing crosslinked with chicoric acid. "Journal of materials chemistry B", 26 Octubre 2018, vol.6, p. 7943-7953
dc.identifier.issn2050-750X
dc.identifier.urihttp://hdl.handle.net/2117/124212
dc.description.abstractThis work describes the enzymatic synthesis of multifunctional hydrogels for chronic wound treatment using thiolated chitosan and the natural polyphenol chicoric acid. Gelation was achieved by laccase-catalyzed oxidation of chicoric acid, a natural compound used for the first time as a homobifunctional crosslinker, reacting subsequently with nucleophilic thiol and amino groups from the chitosan derivative. This approach allowed for twice-faster gelation at three-fold reduced crosslinking reagent concentration, compared to reported enzymatic synthesis of hydrogels using gallic acid as a phenolic provider. Hydrogels with 600 % swelling capacity, coupled to only 20 % weight loss after 6 days in physiological conditions, were obtained. The clinically relevant gram-positive Staphylococcus aureus and the gram-negative Pseudomonas aeruginosa, were reduced by up to 4.5 and 5.5 logs, respectively. A tunable, in the range of 20 - 95 %, ex-vivo inhibition of myeloperoxidase (MPO) activity in chronic wound exudate was achieved, together with control over the total matrix metalloproteinases (MMPs) activities.
dc.language.isoeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshChitosan
dc.subject.lcshBiomedical materials
dc.titleEnzymatic synthesis of a thiolated chitosan-based wound dressing crosslinked with chicoric acid
dc.typeArticle
dc.subject.lemacQuitosan
dc.subject.lemacMaterials biomèdics
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.1039/C8TB02483A
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://pubs.rsc.org/en/Content/ArticleLanding/2018/TB/C8TB02483A#!divAbstract
dc.rights.accessOpen Access
drac.iddocument23450953
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorStefanov, I., Hinojosa, D., Maspoch, S., Hoyo, J., Tzanov, T.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameJournal of materials chemistry B


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