Show simple item record

dc.contributor.authorMestres Beà, Gemma
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2011-04-05T13:52:56Z
dc.date.available2011-04-05T13:52:56Z
dc.date.created2011-04
dc.date.issued2011-04
dc.identifier.citationMestres, G.; Ginebra, M. Novel magnesium phosphate cements with high early strength and antibacterial properties. "Acta biomaterialia", Abril 2011, vol. 7, núm. 4, p. 1853-1861.
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/2117/12249
dc.description.abstractMagnesium phosphate cements (MPCs) have been extensively used as fast setting repair cements in civil engineering. They have properties that are also relevant to biomedical applications, such as fast setting, early strength acquisition and adhesive properties. However, there are some aspects that should be improved before they can be used in the human body, namely their highly exothermic setting reaction and the release of potentially harmful ammonia or ammonium ions. In this paper a new family of MPCs was explored as candidate biomaterials for hard tissue applications. The cements were prepared by mixing magnesium oxide (MgO) with either sodium dihydrogen phosphate (NaH2PO4) or ammonium dihydrogen phosphate (NH4H2PO4), or an equimolar mixture of both. The exothermia and setting kinetics of the new cement formulations were tailored to comply with clinical requirements by adjusting the granularity of the phosphate salt and by using sodium borate as a retardant. The ammonium-containing MPC resulted in struvite (MgNH4PO4 6H2O) as the major reaction product, whereas the MPC prepared with sodium dihydrogen phosphate resulted in an amorphous product. Unreacted magnesium oxide was found in all the formulations. The MPCs studied showed early compressive strengths substantially higher than that of apatitic calcium phosphate cements. The Na-containing MPCs were shown to have antibacterial activity against Streptococcus sanguinis, which was attributed to the alkaline pH developed during the setting reaction.
dc.format.extent9 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials::Metal·lúrgia
dc.subject.lcshMaterials science
dc.titleNovel magnesium phosphate cements with high early strength and antibacterial properties
dc.typeArticle
dc.subject.lemacAssaigs de materials
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.actbio.2010.12.008
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://linkinghub.elsevier.com/retrieve/pii/S1742706110005593
dc.rights.accessRestricted access - publisher's policy
drac.iddocument5437007
dc.description.versionPostprint (published version)
upcommons.citation.authorMestres, G.; Ginebra, M.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameActa biomaterialia
upcommons.citation.volume7
upcommons.citation.number4
upcommons.citation.startingPage1853
upcommons.citation.endingPage1861


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain