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dc.contributor.authorRaymond Llorens, Santiago
dc.contributor.authorMaazouz, Yassine
dc.contributor.authorMontufar Jiménez, Edgar Benjamin
dc.contributor.authorPerez, Roman A.
dc.contributor.authorGonzález Arcos, Borja
dc.contributor.authorKonka, Joanna Magdalena
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.identifier.citationRaymond, S., Maazouz, Y., Montufar, Edgar B., Perez, R., González, B., Konka, J., Ginebra, M.P. Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks. "Acta biomaterialia", 1 Gener 2018, vol. 75, núm. July 2018, p. 451-462.
dc.description.abstractDirect ink writing (DIW) techniques open up new possibilities for the fabrication of patient-specific bone grafts. Self-setting calcium phosphate inks, which harden at low temperature, allow obtaining nanostructured scaffolds with biomimetic properties and enhanced bioactivity. However, the slow hardening kinetics hampers the translation to the clinics. Different hydrothermal treatments for the consolidation of DIW scaffolds fabricated with an a-tricalcium phosphate /pluronic F127 ink were explored, comparing them with a biomimetic treatment. Three different scaffold architectures were analysed. The hardening process, associated to the conversion of a-tricalcium phosphate to hydroxyapatite was drastically accelerated by the hydrothermal treatments, reducing the time for complete reaction from 7¿days to 30 minutes, while preserving the scaffold architectural integrity and retaining the nanostructured features. ß-tricalcium phosphate was formed as a secondary phase, and a change of morphology from plate-like to needle-like crystals in the hydroxyapatite phase was observed. The binder was largely released during the treatment. The hydrothermal treatment resulted in a 30% reduction of the compressive strength, associated to the residual presence of ß-tricalcium phosphate. Biomimetic and hydrothermally treated scaffolds supported the adhesion and proliferation of rat mesenchymal stem cells, indicating a good suitability for bone tissue engineering applications. Statement of Significance 3D plotting has opened up new perspectives in the bone regeneration field allowing the customisation of synthetic bone grafts able to fit patient-specific bone defects. Moreover, this technique allows the control of the scaffolds’ architecture and porosity. The present work introduces a new method to harden biomimetic hydroxyapatite 3D-plotted scaffolds which avoids high-temperature sintering. It has two main advantages: i) it is fast and simple, reducing the whole fabrication process from the several days required for the biomimetic processing to a few hours; and ii) it retains the nanostructured character of biomimetic hydroxyapatite and allows controlling the porosity from the nano- to the macroscale. Moreover, the good in vitro cytocompatibility results support its suitability for cell-based bone regeneration therapies
dc.format.extent12 p.
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshCalcium phosphate
dc.subject.lcshBone regeneration
dc.subject.lcshTissue engineering
dc.subject.otherCalcium phosphate
dc.subject.otherBiomimetic Bone regeneration
dc.subject.other3D plotting
dc.subject.otherDirect ink writing
dc.subject.otherBone graft
dc.titleAccelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks
dc.subject.lemacFosfat de calci
dc.subject.lemacOssos -- Regeneració
dc.subject.lemacEnginyeria de teixits
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
local.citation.authorRaymond, S.; Maazouz, Y.; Montufar, Edgar B.; Perez, R.; González, B.; Konka, J.; Ginebra, M.P.
local.citation.publicationNameActa biomaterialia
local.citation.numberJuly 2018

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