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Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks

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Raymond et al. Acta Biomaterialia 2017 (2,113Mb)
 
10.1016/j.actbio.2018.05.042
 
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hdl:2117/122135

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Raymond Llorens, SantiagoMés informacióMés informació
Maazouz, Yassine
Montufar Jiménez, Edgar Benjamin
Perez, Roman A.
González Arcos, Borja
Konka, Joanna MagdalenaMés informacióMés informació
Ginebra Molins, Maria PauMés informacióMés informacióMés informació
Document typeArticle
Defense date2018-01-01
PublisherElsevier
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Direct ink writing (DIW) techniques open up new possibilities for the fabrication of patient-specific bone grafts. Self-setting calcium phosphate inks, which harden at low temperature, allow obtaining nanostructured scaffolds with biomimetic properties and enhanced bioactivity. However, the slow hardening kinetics hampers the translation to the clinics. Different hydrothermal treatments for the consolidation of DIW scaffolds fabricated with an a-tricalcium phosphate /pluronic F127 ink were explored, comparing them with a biomimetic treatment. Three different scaffold architectures were analysed. The hardening process, associated to the conversion of a-tricalcium phosphate to hydroxyapatite was drastically accelerated by the hydrothermal treatments, reducing the time for complete reaction from 7¿days to 30 minutes, while preserving the scaffold architectural integrity and retaining the nanostructured features. ß-tricalcium phosphate was formed as a secondary phase, and a change of morphology from plate-like to needle-like crystals in the hydroxyapatite phase was observed. The binder was largely released during the treatment. The hydrothermal treatment resulted in a 30% reduction of the compressive strength, associated to the residual presence of ß-tricalcium phosphate. Biomimetic and hydrothermally treated scaffolds supported the adhesion and proliferation of rat mesenchymal stem cells, indicating a good suitability for bone tissue engineering applications. Statement of Significance 3D plotting has opened up new perspectives in the bone regeneration field allowing the customisation of synthetic bone grafts able to fit patient-specific bone defects. Moreover, this technique allows the control of the scaffolds’ architecture and porosity. The present work introduces a new method to harden biomimetic hydroxyapatite 3D-plotted scaffolds which avoids high-temperature sintering. It has two main advantages: i) it is fast and simple, reducing the whole fabrication process from the several days required for the biomimetic processing to a few hours; and ii) it retains the nanostructured character of biomimetic hydroxyapatite and allows controlling the porosity from the nano- to the macroscale. Moreover, the good in vitro cytocompatibility results support its suitability for cell-based bone regeneration therapies
CitationRaymond, S., Maazouz, Y., Montufar, Edgar B., Perez, R., González, B., Konka, J., Ginebra, M.P. Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks. "Acta biomaterialia", 1 Gener 2018, vol. 75, núm. July 2018, p. 451-462. 
URIhttp://hdl.handle.net/2117/122135
DOI10.1016/j.actbio.2018.05.042
ISSN1742-7061
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S1742706118303192
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  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [961]
  • BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [405]
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