Instability and spatiotemporal dynamics of alternans in paced cardiac tissue
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10.1103/PhysRevLett.88.208101
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/12213
Tipus de documentArticle
Data publicació2002
Condicions d'accésAccés obert
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Abstract
We derive an equation that governs the spatiotemporal dynamics of small amplitude alternans in paced
cardiac tissue. We show that a pattern-forming linear instability leads to the spontaneous formation of
stationary or traveling waves whose nodes divide the tissue into regions with opposite phase of oscillation
of action potential duration. This instability is important because it creates dynamically a heterogeneous
electrical substrate for the formation of conduction blocks and the induction of fibrillation if the tissue
size exceeds a fraction of the pattern wavelength. We derive an analytical expression for this wavelength
as a function of three basic length scales related to dispersion and intercellular electrical coupling.
CitacióEchebarria, B.; Karma, A. Instability and spatiotemporal dynamics of alternans in paced cardiac tissue. "Physical review letters", 2002, vol. 88, núm. 20, p. 208101-1-208101-4.
ISSN0031-9007
Versió de l'editorhttp://prl.aps.org/pdf/PRL/v88/i20/e208101
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Phy_Rev_Let_Echebarria_2002.pdf | 179,8Kb | Visualitza/Obre |