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dc.contributor.authorOrtiz Hernández, Mónica
dc.contributor.authorRappe, K.
dc.contributor.authorMolmeneu Trias, Meritxell
dc.contributor.authorMas Moruno, Carlos
dc.contributor.authorGuillem Martí, Jordi
dc.contributor.authorPunset Fuste, Miquel
dc.contributor.authorCaparrós, Cristina
dc.contributor.authorCalero Martínez, José Antonio
dc.contributor.authorFranch, Jordi
dc.contributor.authorFernández Fairén, Mariano
dc.contributor.authorGil, Javier
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2018-10-05T11:14:30Z
dc.date.available2018-10-05T11:14:30Z
dc.date.issued2018-08-30
dc.identifier.citationOrtiz-Hernández, M., Rappe, K., Molmeneu, M., Mas-Moruno, C., Guillem-Marti, J., Punset, M., Caparrós, C., Calero, J., Franch, J., Fernández-Fairén, M., Gil, J. Two different strategies to enhance osseointegration in porous titanium: Inorganic thermo-chemical treatment versus organic coating by peptide adsorption. "International journal of molecular sciences", 30 Agost 2018, vol. 19, núm. 9, p. 2574-1-2574-17.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/2117/121928
dc.description.abstractIn this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshOsseointegration
dc.subject.lcshPorosity
dc.subject.lcshTitanium alloys
dc.subject.othertitanium foams
dc.subject.otherosseointegration
dc.subject.otherporosity
dc.subject.otherbioactive materials
dc.titleTwo different strategies to enhance osseointegration in porous titanium: Inorganic thermo-chemical treatment versus organic coating by peptide adsorption
dc.typeArticle
dc.subject.lemacTitani -- Aliatges
dc.subject.lemacPorositat
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.3390/ijms19092574
dc.relation.publisherversionhttp://www.mdpi.com/1422-0067/19/9/2574
dc.rights.accessOpen Access
local.identifier.drac23345299
dc.description.versionPostprint (published version)
local.citation.authorOrtiz-Hernández, M.; Rappe, K.; Molmeneu, M.; Mas-Moruno, C.; Guillem-Marti, J.; Punset, M.; Caparrós, C.; Calero, J.; Franch, J.; Fernández-Fairén, M.; Gil, J.
local.citation.publicationNameInternational journal of molecular sciences
local.citation.volume19
local.citation.number9
local.citation.startingPage2574-1
local.citation.endingPage2574-17


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