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The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment

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Oliveira et al Acta Biom REVISED_OC_PP.pdf (527,9Kb)
 
10.1016/j.actbio.2015.10.003
 
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hdl:2117/119889

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Oliveira, Hugo
Catros, Sylvain
Boiziau, Claudine
Siadous, Robin
Martí Muñoz, JoanMés informació
Bareille, Reine
Rey, Sylvie
Castaño Linares, ÓscarMés informació
Planell Estany, Josep AntonMés informacióMés informació
Amedee, Joelle
Engel López, ElisabethMés informacióMés informacióMés informació
Document typeArticle
Defense date2016-01-01
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
In current bone tissue engineering strategies the achievement of sufficient angiogenesis during tissue regeneration is still a major limitation in order to attain full functionality. Several strategies have been described to tackle this problem, mainly by the use of angiogenic factors or endothelial progenitor cells. However, when facing a clinical scenario these approaches are inherently complex and present a high cost. As such, more cost effective alternatives are awaited. Here, we demonstrate the potential of electrospun poly(lactic acid) (PLA) fiber-based membranes, containing calcium phosphate ormoglass (CaP) particles, to elicit angiogenesis in vivo, in a subcutaneous model in mice. We show that the current approach elicited the local expression of angiogenic factors, associated to a chemotactic effect on macrophages, and sustained angiogenesis into the biomaterial. As both PLA and CaP are currently accepted for clinical application these off-the-shelf novel membranes have great potential for guided bone regeneration applications.
CitationOliveira, H., Catros, S., Boiziau, C., Siadous, R., Martí-Muñoz, J., Bareille, R., Rey, S., Castaño, O., Planell, J. A., Amedee, J., Engel, E. The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment. "Acta biomaterialia", 1 Gener 2016, vol. 29, p. 435-445. 
URIhttp://hdl.handle.net/2117/119889
DOI10.1016/j.actbio.2015.10.003
ISSN1742-7061
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S1742706115301379
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