The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment
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10.1016/j.actbio.2015.10.003
Inclou dades d'ús des de 2022
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hdl:2117/119889
Tipus de documentArticle
Data publicació2016-01-01
Condicions d'accésAccés obert
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Abstract
In current bone tissue engineering strategies the achievement of sufficient angiogenesis during tissue regeneration is still a major limitation in order to attain full functionality. Several strategies have been described to tackle this problem, mainly by the use of angiogenic factors or endothelial progenitor cells. However, when facing a clinical scenario these approaches are inherently complex and present a high cost. As such, more cost effective alternatives are awaited. Here, we demonstrate the potential of electrospun poly(lactic acid) (PLA) fiber-based membranes, containing calcium phosphate ormoglass (CaP) particles, to elicit angiogenesis in vivo, in a subcutaneous model in mice. We show that the current approach elicited the local expression of angiogenic factors, associated to a chemotactic effect on macrophages, and sustained angiogenesis into the biomaterial. As both PLA and CaP are currently accepted for clinical application these off-the-shelf novel membranes have great potential for guided bone regeneration applications.
CitacióOliveira, H., Catros, S., Boiziau, C., Siadous, R., Martí-Muñoz, J., Bareille, R., Rey, S., Castaño, O., Planell, J. A., Amedee, J., Engel, E. The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment. "Acta biomaterialia", 1 Gener 2016, vol. 29, p. 435-445.
ISSN1742-7061
Versió de l'editorhttp://www.sciencedirect.com/science/article/pii/S1742706115301379
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