Ir al contenido (pulsa Retorno)

Universitat Politècnica de Catalunya

    • Català
    • Castellano
    • English
    • LoginRegisterLog in (no UPC users)
  • mailContact Us
  • world English 
    • Català
    • Castellano
    • English
  • userLogin   
      LoginRegisterLog in (no UPC users)

UPCommons. Global access to UPC knowledge

Banner header
61.694 UPC E-Prints
You are here:
View Item 
  •   DSpace Home
  • E-prints
  • Grups de recerca
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
  • Articles de revista
  • View Item
  •   DSpace Home
  • E-prints
  • Grups de recerca
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
  • Articles de revista
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The proangiogenic potential of a novel calcium releasing composite biomaterial: Orthotopic in vivo evaluation

Thumbnail
View/Open
The proangiogenic potential of a novel calcium releasing composite biomaterial preprint.pdf (1,225Mb)
 
10.1016/j.actbio.2017.02.039
 
  View Usage Statistics
  LA Referencia / Recolecta stats
Cita com:
hdl:2117/119888

Show full item record
Oliveira, Hugo
Catros, Sylvain
Castaño Linares, ÓscarMés informació
Rey, Sylvie
Siadous, Robin
Clift, Douglas
Martí Muñoz, JoanMés informació
Batista, Marc
Bareille, Reine
Planell Estany, Josep AntonMés informacióMés informació
Engel López, ElisabethMés informacióMés informacióMés informació
Amedee, Joelle
Document typeArticle
Defense date2017-05-01
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Insufficient angiogenesis remains a major hurdle in current bone tissue engineering strategies. An extensive body of work has focused on the use of angiogenic factors or endothelial progenitor cells. However, these approaches are inherently complex, in terms of regulatory and methodologic implementation, and present a high cost. We have recently demonstrate the potential of electrospun poly(lactic acid) (PLA) fiber-based membranes, containing calcium phosphate (CaP) ormoglass particles, to elicit angiogenesis in vivo, in a subcutaneous model in mice. Here we have devised an injectable composite, containing CaP glass-ceramic particles, dispersed within a (Hydroxypropyl)methyl cellulose (HPMC) matrix, with the capacity to release calcium in a more sustained fashion. We show that by tuning the release of calcium in vivo, in a rat bone defect model, we could improve both bone formation and increase angiogenesis. The bone regeneration kinetics was dependent on the Ca2+ release rate, with the faster Ca2+ release composite gel showing improved bone repair at 3 weeks, in relation to control. In the same line, improved angiogenesis could be observed for the same gel formulation at 6 weeks post implantation. This methodology allows to integrate two fundamental processes for bone tissue regeneration while using a simple, cost effective, and safe approach. Statement of Significance In current bone tissue engineering approaches the achievement of sufficient angiogenesis, during tissue regeneration, is a major limitation in order to attain full tissue functionality. Recently, we have shown that calcium ions, released by the degradation of calcium phosphate ormoglasses (CaP), are effective angiogenic promoters, in both in vitro and in a subcutaneous implantation model. Here, we devised an injectable composite, containing CaP glass-ceramic particles, dispersed within a HPMC matrix, enabling the release of calcium in a more sustained fashion. We show that by tuning the release of calcium in vivo, in a rat bone defect model, we could improve both bone formation and increase angiogenesis. This simple and cost effective approach holds great promise to translate to the clinics.
CitationOliveira, H., Catros, S., Castaño, O., Rey, S., Siadous, R., Clift, D., Martí-Muñoz, J., Batista, M., Bareille, R., Planell, J. A., Engel, E., Amedee, J. The proangiogenic potential of a novel calcium releasing composite biomaterial: Orthotopic in vivo evaluation. "Acta biomaterialia", 1 Maig 2017, vol. 54, p. 377-385. 
URIhttp://hdl.handle.net/2117/119888
DOI10.1016/j.actbio.2017.02.039
ISSN1742-7061
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S1742706117301459
Collections
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies - Articles de revista [386]
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [961]
  View Usage Statistics

Show full item record

FilesDescriptionSizeFormatView
The proangiogen ... e biomaterial preprint.pdf1,225MbPDFView/Open

Browse

This CollectionBy Issue DateAuthorsOther contributionsTitlesSubjectsThis repositoryCommunities & CollectionsBy Issue DateAuthorsOther contributionsTitlesSubjects

© UPC Obrir en finestra nova . Servei de Biblioteques, Publicacions i Arxius

info.biblioteques@upc.edu

  • About This Repository
  • Contact Us
  • Send Feedback
  • Privacy Settings
  • Inici de la pàgina