Mostra el registre d'ítem simple
Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms
dc.contributor.author | Castaño, Óscar |
dc.contributor.author | Pérez Amodio, Soledad Graciela |
dc.contributor.author | Navarro Requena, Claudia |
dc.contributor.author | Mateos Timoneda, Miguel Ángel |
dc.contributor.author | Engel López, Elisabeth |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2018-07-04T09:05:11Z |
dc.date.available | 2018-07-04T09:05:11Z |
dc.date.issued | 2018-04 |
dc.identifier.citation | Castaño, Ó., Perez, S., Navarro, C., Mateos, M., Engel, E. Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms. "Advanced drug delivery reviews", Abril 2018, vol. 129, p. 97-117. |
dc.identifier.issn | 0169-409X |
dc.identifier.uri | http://hdl.handle.net/2117/118932 |
dc.description.abstract | Skin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signaling molecules that regulate the cellular response and the dynamic remodeling of the extracellular matrix. Nowadays, several therapies that combine biomolecule signals (growth factors and cytokines) and cells are being proposed. However, a lack of reliable evidence of their efficacy, together with associated issues such as high costs, a lack of standardization, no scalable processes, and storage and regulatory issues, are hampering their application. In situ tissue regeneration appears to be a feasible strategy that uses the body’s own capacity for regeneration by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the wound site to promote repair and regeneration. The aim is to engineer instructive systems to regulate the spatio-temporal delivery of proper signaling based on the biological mechanisms of the different events that occur in the host microenvironment. This review describes the current state of the different signal cues used in wound healing and skin regeneration, and their combination with biomaterial supports to create instructive microenvironments for wound healing. |
dc.format.extent | 21 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica |
dc.subject.lcsh | Skin--Regeneration |
dc.subject.lcsh | Wound healing |
dc.subject.other | instructive biomaterials |
dc.subject.other | skin regeneration |
dc.subject.other | wound healing |
dc.subject.other | signaling release |
dc.subject.other | in situ tissue engineering |
dc.title | Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms |
dc.type | Article |
dc.subject.lemac | Ferides i lesions |
dc.subject.lemac | Pell |
dc.contributor.group | Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies |
dc.identifier.doi | 10.1016/j.addr.2018.03.012 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0169409X18300516 |
dc.rights.access | Open Access |
local.identifier.drac | 22530896 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Castaño, Ó.; Perez, S.; Navarro, C.; Mateos, M.; Engel, E. |
local.citation.publicationName | Advanced drug delivery reviews |
local.citation.volume | 129 |
local.citation.startingPage | 97 |
local.citation.endingPage | 117 |
Fitxers d'aquest items
Aquest ítem apareix a les col·leccions següents
-
Articles de revista [398]
-
Articles de revista [960]