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dc.contributor.authorCastaño, Óscar
dc.contributor.authorPérez Amodio, Soledad Graciela
dc.contributor.authorNavarro Requena, Claudia
dc.contributor.authorMateos Timoneda, Miguel Ángel
dc.contributor.authorEngel López, Elisabeth
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2018-07-04T09:05:11Z
dc.date.available2018-07-04T09:05:11Z
dc.date.issued2018-04
dc.identifier.citationCastaño, Ó., Perez, S., Navarro, C., Mateos, M., Engel, E. Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms. "Advanced drug delivery reviews", Abril 2018, vol. 129, p. 97-117.
dc.identifier.issn0169-409X
dc.identifier.urihttp://hdl.handle.net/2117/118932
dc.description.abstractSkin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signaling molecules that regulate the cellular response and the dynamic remodeling of the extracellular matrix. Nowadays, several therapies that combine biomolecule signals (growth factors and cytokines) and cells are being proposed. However, a lack of reliable evidence of their efficacy, together with associated issues such as high costs, a lack of standardization, no scalable processes, and storage and regulatory issues, are hampering their application. In situ tissue regeneration appears to be a feasible strategy that uses the body’s own capacity for regeneration by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the wound site to promote repair and regeneration. The aim is to engineer instructive systems to regulate the spatio-temporal delivery of proper signaling based on the biological mechanisms of the different events that occur in the host microenvironment. This review describes the current state of the different signal cues used in wound healing and skin regeneration, and their combination with biomaterial supports to create instructive microenvironments for wound healing.
dc.format.extent21 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshSkin--Regeneration
dc.subject.lcshWound healing
dc.subject.otherinstructive biomaterials
dc.subject.otherskin regeneration
dc.subject.otherwound healing
dc.subject.othersignaling release
dc.subject.otherin situ tissue engineering
dc.titleInstructive microenvironments in skin wound healing: biomaterials as signal releasing platforms
dc.typeArticle
dc.subject.lemacFerides i lesions
dc.subject.lemacPell
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.identifier.doi10.1016/j.addr.2018.03.012
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0169409X18300516
dc.rights.accessOpen Access
local.identifier.drac22530896
dc.description.versionPostprint (author's final draft)
local.citation.authorCastaño, Ó.; Perez, S.; Navarro, C.; Mateos, M.; Engel, E.
local.citation.publicationNameAdvanced drug delivery reviews
local.citation.volume129
local.citation.startingPage97
local.citation.endingPage117


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