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dc.contributorSáez Viñas, Pablo
dc.contributor.authorRoldán, Lisandro Agustín
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental
dc.description.abstractWounds in multicellular tissue occur regularly through the lifetime of living organisms, and the closure of these gaps is fundamental for their healthy development. From the physiological point of view, the success in this process is of great importance because when misregulated, it can lead to inflammation or and turmogenesis, among other diseases. The wound healing process in epithelial tissue occurs in three different stages. The first one is the assembly of a supra-cellular actomyosin cable and its migration towards the wound edge, which is done through ion signaling and mechanical contractions of the epithelial cells. Later, after its positioning, the cable contracts driving the tissue towards the gap and reducing the wound area. Finally, cell migration towards the interior of the wound ends up sealing the tissue. In this work, a mechanical continuum model for the first two stages is developed and 2D finite element simulations are performed to reproduce experimental cases. The model for the actomyosin cable formation involves the coupling of transient calcium ions transport, with actin fibers and myosin motors recruitment and non-linear mechanics for the tissue behavior. For the contraction stage, the active deformation of the previously formed actomyosin cable is performed. The relative motion of the myosin motors over the actin filaments is modeleded so there exists an active tissue contraction in the direction of those fibers.
dc.publisherUniversitat Politècnica de Catalunya
dc.rightsAttribution 3.0 Spain
dc.subjectÀrees temàtiques de la UPC::Enginyeria civil
dc.subject.otherwound healing
dc.subject.otherchemo-mechanical coupling
dc.subject.othercell mechanics
dc.titleComputational model for the chemo-mechanical mechanism in wound healing
dc.typeMaster thesis
dc.rights.accessOpen Access
dc.audience.mediatorEscola Tècnica Superior d'Enginyers de Camins, Canals i Ports de Barcelona

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Attribution 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution 3.0 Spain