Computational model for the chemo-mechanical mechanism in wound healing
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Cita com:
hdl:2117/117590
Correu electrònic de l'autorlisandroroldangmail.com
Tipus de documentProjecte Final de Màster Oficial
Data2017-06-16
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Reconeixement 3.0 Espanya
Abstract
Wounds in multicellular tissue occur regularly through the lifetime of living organisms, and
the closure of these gaps is fundamental for their healthy development. From the physiological
point of view, the success in this process is of great importance because when misregulated, it can
lead to inflammation or and turmogenesis, among other diseases.
The wound healing process in epithelial tissue occurs in three different stages. The first one
is the assembly of a supra-cellular actomyosin cable and its migration towards the wound edge,
which is done through ion signaling and mechanical contractions of the epithelial cells. Later,
after its positioning, the cable contracts driving the tissue towards the gap and reducing the
wound area. Finally, cell migration towards the interior of the wound ends up sealing the tissue.
In this work, a mechanical continuum model for the first two stages is developed and 2D
finite element simulations are performed to reproduce experimental cases. The model for the
actomyosin cable formation involves the coupling of transient calcium ions transport, with actin
fibers and myosin motors recruitment and non-linear mechanics for the tissue behavior. For the
contraction stage, the active deformation of the previously formed actomyosin cable is performed.
The relative motion of the myosin motors over the actin filaments is modeleded so there exists
an active tissue contraction in the direction of those fibers.
TitulacióMÀSTER UNIVERSITARI EN MÈTODES NUMÈRICS EN ENGINYERIA (Pla 2012)
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TFM_Roldan.pdf | 15,09Mb | Visualitza/Obre |