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dc.contributor.authorGalbis Fuster, Elsa
dc.contributor.authorIglesias González, Nieves
dc.contributor.authorLucas Rodríguez, Ricardo
dc.contributor.authorTinajero, Ernesto
dc.contributor.authorMuñoz Guerra, Sebastián
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2018-05-08T10:40:19Z
dc.date.available2018-05-08T10:40:19Z
dc.date.issued2017-09-25
dc.identifier.citationGalbis, E., Iglesias, N., Lucas, R., Tinajero, E., Muñoz, S. Validation of smart nanoparticles as controlled drug delivery systems: loading and pH-dependent release of pilocarpine. "ACS omega", 25 Setembre 2017, vol. 3, núm. 1, p. 375-382.
dc.identifier.issn2470-1343
dc.identifier.urihttp://hdl.handle.net/2117/117012
dc.description.abstractMicelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the encapsulated substance from the routes of degradation until they reach the site of action. The present work assesses loading kinetics of a hydrophobic drug, pilocarpine, in polymeric micellar nanoparticles (NPs) and its pH-dependent release in hydrophilic environments. The trigger pH stimulus, pH 5.5, was the value encountered in damaged tissues in solid tumors. The new nanoparticles were prepared from an amphiphilic block copolymer, [(HEMA19%-DMA31%)-(FMA5%-DEA45%)]. For the present research, three systems were validated, two of them with cross-linked cores and the other without chemical stabilization. A comparison of their loading kinetics and release profiles is discussed, with the support of additional data obtained by scanning electron microscopy and dynamic light scattering. The drug was loaded into the NPs within the first minutes; the load was dependent on the degree of cross-linking. All of the systems experienced a boost in drug release at acidic pH, ranging from 50 to 80% within the first 48 h. NPs with the highest degree (20%) of core cross-linking delivered the highest percentage of drug at fixed times. The studied systems exhibited fine-tuned sustained release features, which may provide a continuous delivery of the drug at specific acidic locations, thereby diminishing side effects and increasing therapeutic rates. Hence, the studied NPs proved to behave as smart controlled drug delivery systems capable of responding to changes in pH.
dc.format.extent8 p.
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshPilocarpine
dc.subject.lcshDrug delivery systems
dc.subject.otherAmphiphiles
dc.subject.otherCritical micelle concentration
dc.subject.otherDrug delivery systems
dc.subject.otherDrug discovery and Drug delivery systems
dc.subject.otherElectric transport processes and properties
dc.subject.otherMaterials processing
dc.subject.otherPharmaceutical carriers
dc.subject.otherPhysical and chemical processes
dc.titleValidation of smart nanoparticles as controlled drug delivery systems: loading and pH-dependent release of pilocarpine
dc.typeArticle
dc.subject.lemacSistemes d'administració de medicaments
dc.subject.lemacBiotecnologia farmacèutica
dc.contributor.groupUniversitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics
dc.identifier.doi10.1021/acsomega.7b01421
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://pubs.acs.org/doi/full/10.1021/acsomega.7b01421
dc.rights.accessOpen Access
local.identifier.drac22423895
dc.description.versionPostprint (published version)
local.citation.authorGalbis, E.; Iglesias, N.; Lucas, R.; Tinajero, E.; Muñoz, S.
local.citation.publicationNameACS omega
local.citation.volume3
local.citation.number1
local.citation.startingPage375
local.citation.endingPage382


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