Stent de ácido poli-L-láctico cargado con fármaco por impresión 3D
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Inclou dades d'ús des de 2022
Cita com:
hdl:2117/116922
Tipus de documentProjecte Final de Màster Oficial
Data2018-01-25
Condicions d'accésAccés restringit per decisió de l'autor
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industrial corresponents. Sense perjudici de les exempcions legals existents, queda prohibida la seva
reproducció, distribució, comunicació pública o transformació sense l'autorització del titular dels drets
Abstract
Bioresorbable stents made of poly-L-lactic acid (PLLA) compete with classic bare-metal stents thanks
to their biodegradability added to the resolution of the restenosis problem. Nevertheless, they can
lead to late-stent thrombosis. In order to decrease the inflammatory response and the apparition of
blood clots, a drug molecule (acetyl salicylic acid o ASA) will be added to a PLLA stent made by 3D
printing. Firstly, ASA will be dissolved in a solvent and secondly, PLLA will be added to the mix and
dissolved to have a drug uniformly distributed into the stent volume. The solvent is evaporated during
and after printing. The incorporation will be observed with Scanning Electron Microscopy and it will be
concluded that ASA decreases the surface roughness and also that the drug creates agglomerates. The
drug crystallization affects the color of the stent (it becomes white and opaque) and its mechanical
properties (the ink is less elastic and thus more fragile). A drug release assay will be done, submerging
stents with various ASA concentrations in a phosphate buffer solution. Samples of the environment
will be collected regularly for two weeks in order to analyze the evolution of the ASA released
concentration. The concentration will be calculated with UV-vis spectroscopy. It will be concluded that
the liberation rate is higher during the first hours for highly concentrated stents in ASA whereas it is
more linear for lowly concentrated stents. Moreover, a stent with a higher surface will have a high final
percentage of released ASA in comparison with a sent with a small surface.
TitulacióMÀSTER UNIVERSITARI EN CIÈNCIA I ENGINYERIA DE MATERIALS (Pla 2014)
Fitxers | Descripció | Mida | Format | Visualitza |
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250112 Memoria_Mathilde_Fiorletta_final.pdf | Memòria | 14,80Mb | Accés restringit |