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dc.contributor.authorScionti, Giuseppe
dc.contributor.authorRodriguez Arco, Laura
dc.contributor.authorLopez Lopez, Modesto Torcuato
dc.contributor.authorMedina Castillo, Antonio L.
dc.contributor.authorGarzón Bello, Ingrid Johanna
dc.contributor.authorAlaminos Mingorance, Miguel
dc.contributor.authorToledano Perez, Manuel
dc.contributor.authorOsorio Ruiz, Raquel
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2018-04-11T06:53:18Z
dc.date.available2019-03-01T01:30:29Z
dc.date.issued2018-03-01
dc.identifier.citationScionti, G., Rodriguez, L., López-López, M.T., Medina, A., Garzón, I., Alaminos, M., Toledano, M., Osorio, R. Effect of functionalized PHEMA micro- and nano-particles on the viscoelastic properties of fibrin-agarose biomaterials. "Journal of biomedical materials research. Part A", 1 Març 2018, vol. 106, núm. 3, p. 738-745.
dc.identifier.issn1549-3296
dc.identifier.urihttp://hdl.handle.net/2117/116135
dc.description.abstractTwo types of PHEMA-based particles, exhibiting either carboxyl or tertiary ammine functional groups, were incorporated to fibrin-agarose (FA) hydrogels, and the effect of the addition of these synthetic particles on the viscoelastic and microstructural properties of the biomaterials was evaluated. Experimental results indicated that the incorporation of both types of polymeric particles to FA scaffolds was able to improve the biomechanical properties of the biomaterials under steady state and oscillatory shear stresses, resulting in scaffolds characterized by higher values of the storage, loss, and shear moduli. In addition, the microstructural evaluation of the scaffolds showed that the nanoparticles exhibiting carboxyl functional groups were homogeneously distributed across the fibrous network of the hydrogels. The addition of both types of artificial polymeric particles was able to enhance the viscoelastic properties of the FA hydrogels, allowing the biomaterials to reach levels of mechanical consistency under shear stresses in the same range of some human native soft tissues, which could allow these biomaterials to be used as scaffolds for new tissue engineering applications.
dc.format.extent8 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshColloids
dc.subject.lcshBiomedical materials
dc.subject.lcshTissue engineering
dc.subject.otherfibrin
dc.subject.otheragarose
dc.subject.otherfunctionalized particles
dc.subject.otherhydrogel
dc.subject.otherscaffold
dc.titleEffect of functionalized PHEMA micro- and nano-particles on the viscoelastic properties of fibrin-agarose biomaterials
dc.typeArticle
dc.subject.lemacCol·loides
dc.subject.lemacMaterials biomèdics
dc.subject.lemacEnginyeria de teixits
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1002/jbm.a.36275
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pubmed/29052310
dc.rights.accessOpen Access
local.identifier.drac21989934
dc.description.versionPostprint (author's final draft)
local.citation.authorScionti, G.; Rodriguez, L.; López-López, M.T.; Medina, A.; Garzón, I.; Alaminos, M.; Toledano, M.; Osorio, R.
local.citation.publicationNameJournal of biomedical materials research. Part A
local.citation.volume106
local.citation.number3
local.citation.startingPage738
local.citation.endingPage745


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain