Enviaments recents

• The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts 

  Sun, Bo; Wei, Jinhong; Zhong, Xiaowei; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl (2018-07-09)
  Article
  Accés restringit per política de l'editorial

  Sarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ...
• Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans 

  Zhong, Xiaowei; Vallmitjana Lees, Alex; Sun, Bo; Xiao, Zhichao; Benítez Iglesias, Raúl (2018-01-15)
  Article
  Accés restringit per política de l'editorial
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  Calcium alternans produced by increased sarcoplasmic reticulum refractoriness 

  Rodríguez Cantalapiedra, Inma; Lugo Vélez, Carlos Antonio; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (2011-09-29)
  Article
  Accés obert

  Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the ...
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  Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics 

  Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Shiferaw, Yohannes; Echebarría Domínguez, Blas (2016-01-01)
  Article
  Accés obert

  Electromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is ...
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  Propagation malfunctions due to gap junction dysregulation 

  Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (2015-01-02)
  Article
  Accés obert

  Gap junctions are membrane channels that connect the cytoplasm of adjacent cells allowing the cell-to-cell elec- trical coupling necessary for action potential propagation. Pathological conditions, such as malformations ...
• Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans 

  Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2013)
  Article
  Accés restringit per política de l'editorial

  In this work we use a computer model of a ventricular rabbit myocyte to study several factors that affect sarcoplasmic reticulum (SR) calcium load, such as hypercalcemia, SR calcium buffering, or ryanodine receptor ...

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