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Ca2+-CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart
(2021-02-19)
Article
Open AccessRationale: Ca2+ alternans plays an essential role in cardiac alternans that can lead to ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined. Increasing evidence suggests that Ca2+ ... -
Cardiac ryanodine receptor calcium release deficiency syndrome
(2021-02-03)
Article
Open AccessCardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by prominent ventricular ectopy in response to catecholamine stress, which ... -
Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model
(2021-05)
Article
Open AccessGanglioside-induced differentiation associated protein 1 (GDAP1) gene encodes a protein of the mitochondrial outer membrane and of the mitochondrial membrane contacts with the endoplasmic reticulum (MAMs) and lysosomes. ... -
Mitochondria–lysosome membrane contacts are defective in GDAP1-related Charcot–Marie–Tooth disease
(2020-11-06)
Article
Restricted access - publisher's policyMutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the mitochondrial membrane contacts with the endoplasmic ... -
Translational diagnostics: an in-house pipeline to validate genetic variants in children with undiagnosed and rare diseases
(2021-01-13)
Article
Restricted access - publisher's policyDiagnosis is essential for the management and treatment of patients with rare diseases. In a group of patients, the genetic study identifies variants of uncertain significance or inconsistent with the phenotype; therefore, ... -
Diamagnetic interactions in superheated-superconducting granules under an external magnetic field
(2002-11)
Article
Open AccessThe study of the phase transitions produced in ensembles of metastable superconducting granules by magnetic field variations is important both for fundamental physics and for applications in particle detectors. Theoretical ... -
Detection of calcium release from individual RyR2 clusters in cardiomyocites
(2020-02)
Article
Restricted access - publisher's policyCardiac ryanodine receptors (RyR2s) are Ca2þ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2þ release. The distribution of these Ca2þ release ... -
Dynamic and irregular distribution of RyR2 clusters in the periphery of live ventricular myocytes
(2018-01-23)
Article
Open AccessCardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release ... -
Gap junction dynamics induces localized conductance bistability in cardiac tissue
(2019-07-01)
Article
Open AccessConnexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac tissue. We show that the ... -
Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP
(Elsevier, 2020-02-03)
Article
Open AccessFluorescent proteins are useful imaging and theranostic agents, but their potential superiority over alternative dyes is weakened by substantial photobleaching under irradiation. Enhancing protein photostability has been ... -
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
(2019-03-01)
Article
Open AccessAims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying ... -
The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts
(2018-07-09)
Article
Open AccessSarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ...
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