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MedicalSeg: a medical GUI application for image segmentation management
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-06-08)
Article
Open AccessIn the field of medical imaging, the division of an image into meaningful structures using image segmentation is an essential step for pre-processing analysis. Many studies have been carried out to solve the general problem ... -
3D printing with star-shaped strands: a new approach to enhance in vivo bone regeneration
(Elsevier, 2022-06-01)
Article
Open Access
Covenantee: Mimetis Biomaterials / Institut de Recerca Sant Joan de Déu / Universidade de Vigo / Universitat de Barcelona / Universitat Autònoma de Barcelona / Institut de Bioenginyeria de CatalunyaConcave surfaces have shown to promote bone regeneration in vivo. However, bone scaffolds obtained by direct ink writing, one of the most promising approaches for the fabrication of personalized bone grafts, consist mostly ... -
ß2-adrenergic stimulation potentiates spontaneous calcium release by increasing signal mass and co-activation of ryanodine receptor clusters
(2022-04-13)
Article
Open AccessAims It is unknown how ß-adrenergic stimulation affects calcium dynamics in individual RyR2 clusters and leads to the induction of spontaneous calcium waves. To address this, we analysed spontaneous calcium release ... -
Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
(Elsevier, 2021-11-01)
Article
Open Access
Covenantee: Mimetis Biomaterials / Institut de Recerca Sant Joan de Déu / Universitat Autònoma de Barcelona / Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística / Institut de Bioenginyeria de CatalunyaHydrothermal (H) processes accelerate the hydrolysis reaction of a-tricalcium phosphate (a-TCP) compared to the long-established biomimetic (B) treatments. They are of special interest for patient-specific 3D-printed bone ... -
Comparison between experimental digital image processing and numerical methods for stress analysis in dental implants with different restorative materials
(Elsevier, 2021-01-01)
Article
Restricted access - publisher's policyThe aim of this study is to evaluate the stresses transferred to peri-implant areas from single implants restored with different restorative materials and subjected to a static vertical load with low eccentricity. A total ... -
Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation
(2021-03-31)
Article
Open AccessAims Atrial fibrillation (AF) has been associated with intracellular calcium disturbances in human atrial myocytes, but little is known about the potential influence of sex and we here aimed to address this issue. Methods ... -
A 3D finite element analysis model of single implant-supported prosthesis under dynamic impact loading for evaluation of stress in the crown, abutment and cortical bone using different rehabilitation materials
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-24)
Article
Open AccessIn the literature, many researchers investigated static loading effects on an implant. However, dynamic loading under impact loading has not been investigated formally using numerical methods. This study aims to evaluate, ... -
Ca2+-CaM dependent inactivation of RyR2 underlies Ca2+ alternans in intact heart
(2021-02-19)
Article
Open AccessRationale: Ca2+ alternans plays an essential role in cardiac alternans that can lead to ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined. Increasing evidence suggests that Ca2+ ... -
Cardiac ryanodine receptor calcium release deficiency syndrome
(2021-02-03)
Article
Open AccessCardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by prominent ventricular ectopy in response to catecholamine stress, which ... -
Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model
(2021-05)
Article
Open AccessGanglioside-induced differentiation associated protein 1 (GDAP1) gene encodes a protein of the mitochondrial outer membrane and of the mitochondrial membrane contacts with the endoplasmic reticulum (MAMs) and lysosomes. ... -
Mitochondria–lysosome membrane contacts are defective in GDAP1-related Charcot–Marie–Tooth disease
(2020-11-06)
Article
Open AccessMutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the mitochondrial membrane contacts with the endoplasmic ... -
Translational diagnostics: an in-house pipeline to validate genetic variants in children with undiagnosed and rare diseases
(2021-01-13)
Article
Open AccessDiagnosis is essential for the management and treatment of patients with rare diseases. In a group of patients, the genetic study identifies variants of uncertain significance or inconsistent with the phenotype; therefore, ...
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