Articles de revista
Recent Submissions
-
Mitochondria–lysosome membrane contacts are defective in GDAP1-related Charcot–Marie–Tooth disease
(2020-11-06)
Article
Restricted access - publisher's policyMutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the mitochondrial membrane contacts with the endoplasmic ... -
Translational diagnostics: an in-house pipeline to validate genetic variants in children with undiagnosed and rare diseases
(2021-01-13)
Article
Restricted access - publisher's policyDiagnosis is essential for the management and treatment of patients with rare diseases. In a group of patients, the genetic study identifies variants of uncertain significance or inconsistent with the phenotype; therefore, ... -
Diamagnetic interactions in superheated-superconducting granules under an external magnetic field
(2002-11)
Article
Open AccessThe study of the phase transitions produced in ensembles of metastable superconducting granules by magnetic field variations is important both for fundamental physics and for applications in particle detectors. Theoretical ... -
Detection of calcium release from individual RyR2 clusters in cardiomyocites
(2020-02)
Article
Restricted access - publisher's policyCardiac ryanodine receptors (RyR2s) are Ca2þ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2þ release. The distribution of these Ca2þ release ... -
Dynamic and irregular distribution of RyR2 clusters in the periphery of live ventricular myocytes
(2018-01-23)
Article
Open AccessCardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release ... -
Gap junction dynamics induces localized conductance bistability in cardiac tissue
(2019-07-01)
Article
Open AccessConnexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac tissue. We show that the ... -
Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP
(Elsevier, 2020-02-03)
Article
Open AccessFluorescent proteins are useful imaging and theranostic agents, but their potential superiority over alternative dyes is weakened by substantial photobleaching under irradiation. Enhancing protein photostability has been ... -
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
(2019-03-01)
Article
Open AccessAims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying ... -
The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts
(2018-07-09)
Article
Open AccessSarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ... -
Calcium alternans produced by increased sarcoplasmic reticulum refractoriness
(2011-09-29)
Article
Open AccessDespite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the ... -
Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics
(2016-01-01)
Article
Open AccessElectromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is ...