Enviaments recents

  • Calcium alternans produced by increased sarcoplasmic reticulum refractoriness 

    Rodríguez Cantalapiedra, Inma; Lugo Vélez, Carlos Antonio; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (2011-09-29)
    Article
    Accés obert
    Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the ...
  • Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics 

    Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Shiferaw, Yohannes; Echebarría Domínguez, Blas (2016-01-01)
    Article
    Accés obert
    Electromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is ...
  • Propagation malfunctions due to gap junction dysregulation 

    Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (2015-01-02)
    Article
    Accés obert
    Gap junctions are membrane channels that connect the cytoplasm of adjacent cells allowing the cell-to-cell elec- trical coupling necessary for action potential propagation. Pathological conditions, such as malformations ...
  • Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans 

    Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2013)
    Article
    Accés restringit per política de l'editorial
    In this work we use a computer model of a ventricular rabbit myocyte to study several factors that affect sarcoplasmic reticulum (SR) calcium load, such as hypercalcemia, SR calcium buffering, or ryanodine receptor ...

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