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The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts
(2018-07-09)
Article
Open AccessSarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ... -
Calcium alternans produced by increased sarcoplasmic reticulum refractoriness
(2011-09-29)
Article
Open AccessDespite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the ... -
Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics
(2016-01-01)
Article
Open AccessElectromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is ... -
Propagation malfunctions due to gap junction dysregulation
(2015-01-02)
Article
Open AccessGap junctions are membrane channels that connect the cytoplasm of adjacent cells allowing the cell-to-cell elec- trical coupling necessary for action potential propagation. Pathological conditions, such as malformations ... -
Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans
(2013)
Article
Restricted access - publisher's policyIn this work we use a computer model of a ventricular rabbit myocyte to study several factors that affect sarcoplasmic reticulum (SR) calcium load, such as hypercalcemia, SR calcium buffering, or ryanodine receptor ...
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