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dc.contributor.authorCarriel, Victor
dc.contributor.authorScionti, Giuseppe
dc.contributor.authorCampos, Fernando
dc.contributor.authorRoda, Olga
dc.contributor.authorCastro, Begoña
dc.contributor.authorCornelissen, Maria
dc.contributor.authorGarzón Bello, Ingrid Johanna
dc.contributor.authorAlaminos Mingorance, Miguel
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2018-04-04T07:42:07Z
dc.date.available2018-04-04T07:42:07Z
dc.date.issued2015-07-14
dc.identifier.citationCarriel, V., Scionti, G., Campos, F., Roda, O., Castro, B., Cornelissen, M., Garzón, I., Alaminos, M. In vitro characterization of a nanostructured fibrin agarose bio-artificial nerve substitute. "Journal of tissue engineering and regenerative medicine", 14 Juliol 2015, vol. 11, núm. 5, p. 1412-1426.
dc.identifier.issn1932-6254
dc.identifier.urihttp://hdl.handle.net/2117/115898
dc.description"This is the peer reviewed version of the following article: Carriel, V., Scionti, G., Campos, F., Roda, O., Castro, B., Cornelissen, M., Garzón, I., and Alaminos, M. (2017) In vitro characterization of a nanostructured fibrin agarose bio-artificial nerve substitute. J Tissue Eng Regen Med, 11: 1412–1426., which has been published in final form at [10.1002/term.2039. . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
dc.description.abstractNeural tissue engineering is focused on the design of novel biocompatible substitutes to repair peripheral nerve injuries. In this paper we describe a nanostructured fibrin–agarose bioartificial nerve substitute (NFABNS), based on nanostructured fibrin–agarose hydrogels (FAHs) with human adipose-derived mesenchymal stem cells (HADMSCs). These NFABNSs were mechanically characterized and HADMSCs behaviour was evaluated using histological and ultrastructural techniques. Mechanical characterization showed that the NFABNSs were resistant, flexible and elastic, with a high deformation capability. Histological analyses carried out in vitro during 16 days revealed that the number of HADMSCs decreased over time, with a significant increase after 16 days. HADMSCs formed cell clusters and degraded the surrounding scaffold during this time; additionally, HADMSCs showed active cell proliferation and cytoskeletal remodelling, with a progressive synthesis of extracellular matrix molecules. Finally, this study demonstrated that it is possible to generate biologically active and mechanically stable tissue-like substitutes with specific dimensions, based on the use of HADMSCs, FAHs and a nanostructure technique. However, in vivo analyses are needed to demonstrate their potential usefulness in peripheral nerve repair
dc.format.extent15 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshBiomedical engineering
dc.subject.lcshNeural networks (Neurobiology)
dc.subject.lcshNanostructured materials
dc.subject.lcshTissue engineering
dc.subject.otherNeural tissue engineering
dc.subject.otherbiomimetic nerve substitute
dc.subject.otherfibrin–agarose hydrogels
dc.subject.othernanostructured biomaterials
dc.subject.otheradipose-derived mesenchymal stem cells
dc.subject.otherextracellular matrix
dc.subject.othercell–biomaterial interactions
dc.titleIn vitro characterization of a nanostructured fibrin agarose bio-artificial nerve substitute
dc.typeArticle
dc.subject.lemacEnginyeria biomèdica
dc.subject.lemacNeurologia
dc.subject.lemacMaterials nanoestructurals
dc.subject.lemacEnginyeria de teixits
dc.identifier.doi10.1002/term.2039
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/term.2039/abstract
dc.rights.accessOpen Access
drac.iddocument17546623
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorCarriel, V.; Scionti, G.; Campos, F.; Roda, O.; Castro, B.; Cornelissen, M.; Garzón, I.; Alaminos, M.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameJournal of tissue engineering and regenerative medicine
upcommons.citation.volume11
upcommons.citation.number5
upcommons.citation.startingPage1412
upcommons.citation.endingPage1426


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Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain