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Dynamic and irregular distribution of RyR2 clusters in the periphery of live ventricular myocytes
(2018-01-23)
Article.
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Article.
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Cardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release ...
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
(2019-03-01)
Article.
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Article.
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Aims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying ...
The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts
(2018-07-09)
Article.
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Article.
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Sarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ...
Calcium alternans produced by increased sarcoplasmic reticulum refractoriness
(2011-09-29)
Article.
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Article.
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Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the ...
Identifying basketball plays from sensor data; towards a low-cost automatic extraction of advanced statistics
(Institute of Electrical and Electronics Engineers (IEEE), 2017)
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Text en actes de congrés.
Accés restringit per política de l'editorial
Advanced statistics have proved to be a crucial tool for basketball coaches in order to improve training skills. Indeed, the performance of the team can be further optimized by studying the behaviour of players under certain ...
Effects of small conductance calcium activated potassium channels in atrial myocytes
(IEEE Computer Society Conference Publishing Services (CPS), 2017)
Comunicació de congrés.
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Comunicació de congrés.
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Among the different potassium channels present in cardiac myocytes, the small conductance Ca2+ activated potassium channels (SK channels) are particular because they are affected by changes in intracellular calcium. The ...
Gap junction dynamics induces localized conductance bistability in cardiac tissue
(2019-07-01)
Article.
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Article.
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Connexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac tissue. We show that the ...
Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans
(2013)
Article.
Accés restringit per política de l'editorial
Article.
Accés restringit per política de l'editorial
In this work we use a computer model of a ventricular
rabbit myocyte to study several factors that affect sarcoplasmic
reticulum (SR) calcium load, such as hypercalcemia,
SR calcium buffering, or ryanodine receptor ...
Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics
(2016-01-01)
Article.
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Article.
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Electromechanical alternans is a beat-to-beat alterna-
tion in the strength of contraction of a cardiac cell which
appears often due to an instability of calcium cycling. The
global calcium signal in cardiomyocytes is ...