El grup realitza estudis experimentals amb cardiomiòcits fent servir tècniques de microscòpia fluorescència i desenvolupa noves tècniques de tractament i anàlisi d'imatges per caracteritzar fenòmens associats a la dinàmica de calci a nivell molecular, subcel·lular i cel·lular. L'objectiu principal és identificar els mecanismes cel·lulars i moleculars associats a la funció cardíaca.

Recent Submissions

  • Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation 

    Herraiz Martínez, Adela; Tarifa Lora, Carmen; Jiménez Sábado, Verónica; Llach Martínez, Ana; Colino-Lage, Hildegard; Nolla Colomer, Carme; Benítez Iglesias, Raúl; Ciruela, Francisco; Cinca Cuscullola, Juan Maria; Hove-Madsen, Leif (2021-03-31)
    Article
    Open Access
    Aims Atrial fibrillation (AF) has been associated with intracellular calcium disturbances in human atrial myocytes, but little is known about the potential influence of sex and we here aimed to address this issue. Methods ...
  • A 3D finite element analysis model of single implant-supported prosthesis under dynamic impact loading for evaluation of stress in the crown, abutment and cortical bone using different rehabilitation materials 

    Cantó Navés, Oriol; Medina Gálvez, Raul; Marimon Serra, Xavier; Ferrer Ballester, Miquel; Figueras Álvarez, Óscar; Cabratosa Termes, Josep (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-24)
    Article
    Open Access
    In the literature, many researchers investigated static loading effects on an implant. However, dynamic loading under impact loading has not been investigated formally using numerical methods. This study aims to evaluate, ...
  • Ca2+-CaM dependent inactivation of RyR2 underlies Ca2+ alternans in intact heart 

    Guo, Wenting; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Álvarez Lacalle, Enrique; Echebarría Domínguez, Blas (2021-02-19)
    Article
    Open Access
    Rationale: Ca2+ alternans plays an essential role in cardiac alternans that can lead to ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined. Increasing evidence suggests that Ca2+ ...
  • Cardiac ryanodine receptor calcium release deficiency syndrome 

    Guo, Wenting; Benítez Iglesias, Raúl; Hove-Madsen, Leif (2021-02-03)
    Article
    Open Access
    Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by prominent ventricular ectopy in response to catecholamine stress, which ...
  • Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model 

    Civera Tregón, Azahara; Benítez Iglesias, Raúl; Hoenicka, Janet; Palau, Francesc (2021-05)
    Article
    Open Access
    Ganglioside-induced differentiation associated protein 1 (GDAP1) gene encodes a protein of the mitochondrial outer membrane and of the mitochondrial membrane contacts with the endoplasmic reticulum (MAMs) and lysosomes. ...
  • Two-variable nullcline analysis of ionic general equilibrium predicts calcium homeostasis in ventricular myocytes 

    Conesa Ortega, David; Echebarría Domínguez, Blas; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Shiferaw, Yohannes; Álvarez Lacalle, Enrique (2020-06-01)
    Contribution to periodical
    Open Access
    Ventricular contraction is roughly proportional to the amount of calcium released from the Sarcoplasmic Reticulum (SR) during systole. While it is rather straightforward to measure calcium levels and contractibility under ...
  • Mitochondria–lysosome membrane contacts are defective in GDAP1-related Charcot–Marie–Tooth disease 

    Cantarero, Lara; Juárez Escoto, Elena; Civera Tregón, Azahara; Rodríguez Sanz, María; Roldán, Mónica; Benítez Iglesias, Raúl; Hoenicka, Janet; Palau, Francesc (2020-11-06)
    Article
    Open Access
    Mutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the mitochondrial membrane contacts with the endoplasmic ...
  • Translational diagnostics: an in-house pipeline to validate genetic variants in children with undiagnosed and rare diseases 

    Pijuan Casas, Jordi; Rodríguez Sanz, Maica; Cortez, Carolina; Altimir, A; Afonso Rodriguez, Carmen Nieves; Benítez Iglesias, Raúl; do Nascimento, Anderson Thiago (2021-01-13)
    Article
    Restricted access - publisher's policy
    Diagnosis is essential for the management and treatment of patients with rare diseases. In a group of patients, the genetic study identifies variants of uncertain significance or inconsistent with the phenotype; therefore, ...
  • Diamagnetic interactions in superheated-superconducting granules under an external magnetic field 

    Peñaranda Ayllón, Angelina; Auguet Sangrá, Carlota E.; Ramírez de la Piscina Millán, Laureano; Girard, Tom A. (2002-11)
    Article
    Open Access
    The study of the phase transitions produced in ensembles of metastable superconducting granules by magnetic field variations is important both for fundamental physics and for applications in particle detectors. Theoretical ...
  • Detection of calcium release from individual RyR2 clusters in cardiomyocites 

    Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Hove-Madsen, Leif; Benítez Iglesias, Raúl (2020-02)
    Article
    Restricted access - publisher's policy
    Cardiac ryanodine receptors (RyR2s) are Ca2þ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2þ release. The distribution of these Ca2þ release ...
  • Dynamic and irregular distribution of RyR2 clusters in the periphery of live ventricular myocytes 

    Hiess, Florian; Detampel, Pascal; Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Ganguly, Anutosh; Amrein, Matthias; ter Keurs, Henk E.D.J; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Chen, S. R. Wayne (2018-01-23)
    Article
    Open Access
    Cardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release ...
  • Gap junction dynamics induces localized conductance bistability in cardiac tissue 

    Hawks, Claudia; Elorza Barbajero, Jorge; Witt, Annette; Laroze, David; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas; Bragard, Jean (2019-07-01)
    Article
    Open Access
    Connexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac tissue. We show that the ...

View more