El grup realitza estudis experimentals amb cardiomiòcits fent servir tècniques de microscòpia fluorescència i desenvolupa noves tècniques de tractament i anàlisi d'imatges per caracteritzar fenòmens associats a la dinàmica de calci a nivell molecular, subcel·lular i cel·lular. L'objectiu principal és identificar els mecanismes cel·lulars i moleculars associats a la funció cardíaca.

Enviaments recents

  • Two-variable nullcline analysis of ionic general equilibrium predicts calcium homeostasis in ventricular myocytes 

    Conesa Ortega, David; Echebarría Domínguez, Blas; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Shiferaw, Yohannes; Álvarez Lacalle, Enrique (2020-06-01)
    Article de premsa
    Accés obert
    Ventricular contraction is roughly proportional to the amount of calcium released from the Sarcoplasmic Reticulum (SR) during systole. While it is rather straightforward to measure calcium levels and contractibility under ...
  • Mitochondria–lysosome membrane contacts are defective in GDAP1-related Charcot–Marie–Tooth disease 

    Cantarero, Lara; Juárez Escoto, Elena; Civera Tregón, Azahara; Rodríguez Sanz, María; Roldán, Mónica; Benítez Iglesias, Raúl; Hoenicka, Janet; Palau, Francesc (2020-11-06)
    Article
    Accés restringit per política de l'editorial
    Mutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the mitochondrial membrane contacts with the endoplasmic ...
  • Translational diagnostics: an in-house pipeline to validate genetic variants in children with undiagnosed and rare diseases 

    Pijuan Casas, Jordi; Rodríguez Sanz, Maica; Cortez, Carolina; Altimir, A; Afonso Rodriguez, Carmen Nieves; Benítez Iglesias, Raúl; do Nascimento, Anderson Thiago (2021-01-13)
    Article
    Accés restringit per política de l'editorial
    Diagnosis is essential for the management and treatment of patients with rare diseases. In a group of patients, the genetic study identifies variants of uncertain significance or inconsistent with the phenotype; therefore, ...
  • Diamagnetic interactions in superheated-superconducting granules under an external magnetic field 

    Peñaranda Ayllón, Angelina; Auguet Sangrá, Carlota E.; Ramírez de la Piscina Millán, Laureano; Girard, Tom A. (2002-11)
    Article
    Accés obert
    The study of the phase transitions produced in ensembles of metastable superconducting granules by magnetic field variations is important both for fundamental physics and for applications in particle detectors. Theoretical ...
  • Detection of calcium release from individual RyR2 clusters in cardiomyocites 

    Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Hove-Madsen, Leif; Benítez Iglesias, Raúl (2020-02)
    Article
    Accés restringit per política de l'editorial
    Cardiac ryanodine receptors (RyR2s) are Ca2þ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2þ release. The distribution of these Ca2þ release ...
  • Dynamic and irregular distribution of RyR2 clusters in the periphery of live ventricular myocytes 

    Hiess, Florian; Detampel, Pascal; Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Ganguly, Anutosh; Amrein, Matthias; ter Keurs, Henk E.D.J; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Chen, S. R. Wayne (2018-01-23)
    Article
    Accés obert
    Cardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release ...
  • Gap junction dynamics induces localized conductance bistability in cardiac tissue 

    Hawks, Claudia; Elorza Barbajero, Jorge; Witt, Annette; Laroze, David; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas; Bragard, Jean (2019-07-01)
    Article
    Accés obert
    Connexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac tissue. We show that the ...
  • Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP 

    Unzueta, Ugutz; Roldán Molina, Mónica; Pesarrodona, Mireia; Benítez Iglesias, Raúl; Sanchez Chardi, Alejandro; Conchillo, Oscar; Mangues, Ramón; Villaverde, Antonio; Vazquez Gómez, Esther (Elsevier, 2020-02-03)
    Article
    Accés restringit per política de l'editorial
    Fluorescent proteins are useful imaging and theranostic agents, but their potential superiority over alternative dyes is weakened by substantial photobleaching under irradiation. Enhancing protein photostability has been ...
  • The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis 

    Herraiz Martínez, Adela; Llach Martínez, Anna; Tarifa Lora, Carmen; Gandía, Jorge; Jiménez Sábado, Verónica; Lozano Velasco, Estefanía; Serra Pascual, Selma A.; Vallmitjana Lees, Alexander; Vázquez Ruiz de Castroviejo, Eduardo; Benítez Iglesias, Raúl (2019-03-01)
    Article
    Accés obert
    Aims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying ...
  • Nonlinearities due to refractoriness in SR Ca release 

    Peñaranda Ayllón, Angelina; Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma; Echebarría Domínguez, Blas (Institute of Electrical and Electronics Engineers (IEEE), 2013-01-01)
    Comunicació de congrés
    Accés obert
    Calcium alternans is a pro-arrhytmic cardiac dysfunction related to beat-to-beat changes in the amplitude of intracellular calcium transient, that typically occurs at rapid pacing rates. Although oscillations in sarcoplasmic ...
  • A General Equilibrium Model to Study Intracellular Calcium Homeostasis. New Insights on Ventricular Function 

    Álvarez Lacalle, Enrique; Conesa Ortega, David; Echebarría Domínguez, Blas; Shiferaw, Yohannes; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma (2018)
    Text en actes de congrés
    Accés obert
  • Identifying basketball plays from sensor data; towards a low-cost automatic extraction of advanced statistics 

    Arbués Sangüesa, Adrià; Moeslund, Thomas B.; Bahnsen, Chris H.; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2017)
    Text en actes de congrés
    Accés restringit per política de l'editorial
    Advanced statistics have proved to be a crucial tool for basketball coaches in order to improve training skills. Indeed, the performance of the team can be further optimized by studying the behaviour of players under certain ...

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