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dc.contributor.authorMas Moruno, Carlos
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2018-03-09T09:37:17Z
dc.date.issued2018
dc.identifier.citationMas-Moruno, C. Surface functionalization of biomaterials for bone tissue regeneration and repair. A: "Peptides and proteins as biomaterials for tissue regeneration and repair". 2018, p. 73-100.
dc.identifier.urihttp://hdl.handle.net/2117/114973
dc.description.abstractBiomaterials have evolved from mere bioinert substrates, required only to passively support cell adhesion and growth, to bioactive cell-instructive surfaces with the capacity to tune cell behavior and dictate cell differentiation. Biofunctionalization stands out as a versatile approach to address such ambitious goal. This strategy relies on the use of cell signaling biomolecules derived from the extracellular matrix and aims to mimic the microenvironment of cell-matrix interactions to harness cell behavior and guide tissue regeneration. In the field of bone tissue engineering, surface functionalization has classically been addressed by using proteins and peptides from the extracellular matrix of bone. However, both approaches are not exempt from limitations, and newer strategies have been proposed as promising alternatives to achieve optimal levels of bone growth and the successful osseointegration of implantable biomaterials. In this regard, integrin selective peptidomimetics and multifunctional systems constitute a new paradigm in surface functionalization. This work will review these strategies, with special emphasis in the concept of multifunctionality.
dc.format.extent28 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshBiomedical materials
dc.titleSurface functionalization of biomaterials for bone tissue regeneration and repair
dc.typePart of book or chapter of book
dc.subject.lemacMaterials biomèdics
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/B978-0-08-100803-4.00003-6
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/B9780081008034000036
dc.rights.accessRestricted access - publisher's policy
drac.iddocument21991753
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
upcommons.citation.authorMas-Moruno, C.
upcommons.citation.publishedtrue
upcommons.citation.publicationNamePeptides and proteins as biomaterials for tissue regeneration and repair
upcommons.citation.startingPage73
upcommons.citation.endingPage100


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