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dc.contributor.authorSaurí, J.
dc.contributor.authorZachariah, Manesh
dc.contributor.authorMacovez, Roberto
dc.contributor.authorTamarit Mur, José Luis
dc.contributor.authorMillán, Daniel
dc.contributor.authorSuñé Pou, M.
dc.contributor.authorGarcía Montoya, E.
dc.contributor.authorPérez Lozano, P.
dc.contributor.authorMiñarro, M.
dc.contributor.authorTicó, J. R.
dc.contributor.authorSuñé Negr, J. M.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2018-03-07T14:18:14Z
dc.date.available2018-03-07T14:18:14Z
dc.date.issued2017-12-01
dc.identifier.citationSaurí, J., Zachariah, M., Macovez, R., Tamarit, J. Ll., Millán, D., Suñé, M., García, E., Pérez, P., Miñarro, M., Ticó, J., Suñé, J. Formulation and characterization of mucoadhesive controlled release matrix tablets of captopril. "Journal of drug delivery science and technology", 1 Desembre 2017, vol. 42, p. 215-226.
dc.identifier.issn1773-2247
dc.identifier.urihttp://hdl.handle.net/2117/114902
dc.description.abstractThe purpose of this study is to characterize controlled release matrix tablets of captopril and to find out the physicochemical properties that have an effect on the mucoadhesion process. The hydrophilic matrix tablets contain captopril, microcrystalline cellulose, barium sulfate, ascorbic acid, ethylcellulose N100, hydroxypropylmethylcellulose K15M, talc, magnesium stearate and colloidal silicon dioxide. The physicochemical properties of the formulations have been characterized using confocal microscopy, contact angle, and scanning electron microscopy. The potential mucoadhesion capabilities of the formulations were assessed measuring the surface free energy, the polar and dispersive forces, the spreading coefficients, the surface roughness, and the network structure of the hydrophilic matrix tablets. The results show that when the concentration of HPMC K15M increases, the spreading coefficients of polymer over mucus and mucus over polymer are more positive, thus increasing the contact between the matrix tablets with the mucus layer. The formulation that contains 15% of HPMC K15M is the formulation that presents a greater swelling capacity, a greater increase in surface roughness, and larger pores within the matrix. This formulation has a higher chain mobility and more free macromolecular chains able to diffuse in the mucus layer. Therefore, this formulation has the greatest potential mucoadhesion capability.
dc.format.extent12 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshChemistry, Physical and theoretical
dc.subject.otherMucoadhesion
dc.subject.otherDrug release
dc.subject.otherHydrophilic matrix tablets
dc.subject.otherQuality by design
dc.subject.otherBroadband dielectric spectroscopy
dc.titleFormulation and characterization of mucoadhesive controlled release matrix tablets of captopril
dc.typeArticle
dc.subject.lemacFisicoquímica
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.identifier.doi10.1016/j.jddst.2017.03.009
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1773224717300527?via%3Dihub
dc.rights.accessOpen Access
local.identifier.drac21625799
dc.description.versionPostprint (author's final draft)
local.citation.authorSaurí, J.; Zachariah, M.; Macovez, R.; Tamarit, J. Ll.; Millán, D.; Suñé, M.; García, E.; Pérez, P.; Miñarro, M.; Ticó, J.; Suñé, J.
local.citation.publicationNameJournal of drug delivery science and technology
local.citation.volume42
local.citation.startingPage215
local.citation.endingPage226


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