Show simple item record

dc.contributor.authorPérez-Mañá, Clara
dc.contributor.authorFarré, Magí
dc.contributor.authorPastor, Antoni
dc.contributor.authorFonseca, Francina
dc.contributor.authorTorrens, Marta
dc.contributor.authorMenoyo, Ester
dc.contributor.authorPujadas, Mitona
dc.contributor.authorFrias, Silvia
dc.contributor.authorLangohr, Klaus
dc.contributor.authorDe la Torre Fornell, Rafael
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.date.accessioned2018-03-06T09:09:32Z
dc.date.available2018-09-01T00:30:41Z
dc.date.issued2017-09-01
dc.identifier.citationPérez-Mañá, C., Farré, M., Pastor, A., Fonseca, F., Torrens, M., Menoyo, E., Pujadas, M., Frias, S., Langohr, K., De la Torre, R. Non-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol. "Alcohol and alcoholism", 1 Setembre 2017, vol. 52, núm. 5, p. 587-594.
dc.identifier.issn0735-0414
dc.identifier.urihttp://hdl.handle.net/2117/114838
dc.description.abstractAims Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The aim was to describe the time courses of both biomarkers after ingestion of acute low–moderate doses of ethanol. Methods The study design was double-blind, randomized, crossover and controlled with placebo. Participants were distributed in three different cohorts: (a) Cohort-1: two doses of 18 and 30 g of ethanol and placebo were administered to 12 subjects; (b) Cohort-2: two doses of 6 and 12 g of ethanol and placebo were administered to six subjects and (c) Cohort-3: two doses of 24 and 42 g of ethanol and placebo were administered to six subjects. Each participant received two doses of ethanol and placebo. Plasma concentrations (0–6 h) of ethanol and specific FAEEs (palmitic, stearic, linoleic and oleic acid ethyl esters) and urinary concentrations of EtG (0–24 h) were measured. Results A dose-dependent increase in blood ethanol concentrations was observed. EtG excretion and FAEEs plasmatic concentrations showed a disproportionate increase with the ethanol dose suggesting non-linearity. Area under the curve (AUC0-6h) of ethanol concentrations showed a linear trend with non-oxidative metabolites’ concentrations. Conclusion The formation rate of ethanol non-oxidative biomarkers does not follow a linear trend, explained mainly by a disproportionate increase in AUC0-6h of ethanol concentrations in relation to dose. This observation should be taken into account when interpreting results in biological matrices in clinical and forensic settings. Short summary A double-blind, randomized, crossover and controlled study was conducted administering ethanol (6–42 g). Ethyl glucuronide (EtG) excretion and fatty acid ethyl esters (FAEEs) plasmatic concentrations showed a disproportionate increase with the ethanol dose suggesting non-linearity. This observation should be taken into account when interpreting biomarker concentrations in clinical settings.
dc.format.extent8 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica
dc.subject.lcshNumerical analysis--Simulation methods
dc.subject.lcshCombinatorial probabilities
dc.subject.otherAlcohol
dc.subject.otherbiomarkers
dc.subject.otherethanol
dc.subject.otherethyl glucuronide
dc.subject.otherfatty acid ethyl esters
dc.titleNon-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol
dc.typeArticle
dc.subject.lemacAnàlisi numèrica
dc.subject.lemacProbabilitats
dc.contributor.groupUniversitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.identifier.doi10.1093/alcalc/agx033
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::65 Numerical analysis::65C Probabilistic methods, simulation and stochastic differential equations
dc.subject.amsClassificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability
dc.relation.publisherversionhttps://academic.oup.com/alcalc/article-abstract/52/5/587/3862033?redirectedFrom=fulltext
dc.rights.accessOpen Access
local.identifier.drac21548748
dc.description.versionPostprint (author's final draft)
local.citation.authorPérez-Mañá, C.; Farré, M.; Pastor, A.; Fonseca, F.; Torrens, M.; Menoyo, E.; Pujadas, M.; Frias, S.; Langohr, K.; De la Torre, R.
local.citation.publicationNameAlcohol and alcoholism
local.citation.volume52
local.citation.number5
local.citation.startingPage587
local.citation.endingPage594


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

All rights reserved. This work is protected by the corresponding intellectual and industrial property rights. Without prejudice to any existing legal exemptions, reproduction, distribution, public communication or transformation of this work are prohibited without permission of the copyright holder