Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
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Inclou dades d'ús des de 2022
Cita com:
hdl:2117/114361
Tipus de documentArticle
Data publicació2018-02-21
EditorOSA
Condicions d'accésAccés obert
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
ProjecteMEDical PHOTonics platform for AGEing (MEDPHOTAGE): Plataforma fotónica, no invasiva, tipo "point-of-care", para la evaluación del riesgo cerebrovascular asociado con el envejecimiento (MINECO-DTS16%2F00087)
LASERLAB-EUROPE - The Integrated Initiative of European Laser Research Infrastructures (EC-H2020-654148)
LASERLAB-EUROPE - The Integrated Initiative of European Laser Research Infrastructures (EC-H2020-654148)
Abstract
In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2.5 hours after rtPA bolus. The increases were faster and higher in the ipsilesional hemisphere. The results show that bedside optical monitoring can detect the effect of reperfusion therapy for ischemic stroke in real-time.
CitacióDelgado-Mederos, R. [et al.]. Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke. "Biomedical Optics Express", 21 Febrer 2018, vol. 9, núm. 3, p. 1262-1271.
ISSN2156-7085
Versió de l'editorhttps://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-3-1262
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