Mostra el registre d'ítem simple

dc.contributor.authorGoday Arno, Albert
dc.contributor.authorFarré, Magí
dc.contributor.authorRodriguez Morato, Jose
dc.contributor.authorRamon, Jose M.
dc.contributor.authorPerez Maña, Clara
dc.contributor.authorPapaseit, Esther
dc.contributor.authorCivit, Ester
dc.contributor.authorLangohr, Klaus
dc.contributor.authorLi Carbo, Marcel
dc.contributor.authorDe la Torre Fornell, Rafael
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.date.accessioned2018-02-13T14:15:58Z
dc.date.available2018-12-01T01:31:21Z
dc.date.issued2017-05-30
dc.identifier.citationGoday, A., Farré, M., Rodriguez, J., Ramon, J., Perez, C., Papaseit, E., Civit, E., Langohr, K., Li Carbo, M., De la Torre, R. Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism. "Obesity Surgery", 30 Maig 2017, vol. 27, núm. 12, p. 3194-3201.
dc.identifier.issn1708-0428
dc.identifier.urihttp://hdl.handle.net/2117/114078
dc.description.abstractThe purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). In the present prospective study, we studied 24 morbid obese patients before, at 4 weeks, and 6 months after having undergone sleeve gastrectomy (n = 10) or Roux-en-Y gastric bypass (n = 14). For comparative purposes, 28 healthy controls (14 normal weights and 14 overweights) were also included in the study. Paracetamol pharmacokinetics was altered in the obese participants leading to lower bioavailability. Bariatric surgery resulted in faster absorption and normalized pharmacokinetic parameters, prompting an increase in paracetamol bioavailability. No differences were found between surgical procedures. In the case of caffeine, the ratio paraxanthine/caffeine did not differ between morbid obese and healthy individuals. This ratio remained unmodified after surgery, indicating that the liver function (assessed by cytochrome P450 1A2 activity) was unaffected by obesity or bariatric surgery. Paracetamol pharmacokinetics and caffeine plasma levels are altered in severely obese patients. The two studied bariatric surgical techniques normalize paracetamol oral bioavailability without impairing the liver function (measured by cytochrome P450 1A2 activity).
dc.format.extent8 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat
dc.subject.lcshCombinatorial analysis
dc.subject.lcshCombinatorial probabilities
dc.subject.lcshBiomathematics
dc.subject.otherClinical trial
dc.subject.otherGastric bypass
dc.subject.otherSleeve gastrectomy
dc.subject.otherMorbid obesity
dc.subject.otherMetabolism paracetamol
dc.subject.otherCaffeine.
dc.titlePharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism
dc.typeArticle
dc.subject.lemacCombinatòria
dc.subject.lemacProbabilitats
dc.subject.lemacBiomatemàtica
dc.contributor.groupUniversitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.identifier.doi10.1007/s11695-017-2745-z
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::05 Combinatorics::05B Designs and configurations
dc.subject.amsClassificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability
dc.subject.amsClassificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs11695-017-2745-z
dc.rights.accessOpen Access
local.identifier.drac21087394
dc.description.versionPostprint (author's final draft)
local.citation.authorGoday, A.; Farré, M.; Rodriguez, J.; Ramon, J.; Perez, C.; Papaseit, E.; Civit, E.; Langohr, K.; Li Carbo, M.; De la Torre, R.
local.citation.publicationNameObesity Surgery
local.citation.volume27
local.citation.number12
local.citation.startingPage3194
local.citation.endingPage3201


Fitxers d'aquest items

Thumbnail

Aquest ítem apareix a les col·leccions següents

Mostra el registre d'ítem simple