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Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism
dc.contributor.author | Goday Arno, Albert |
dc.contributor.author | Farré, Magí |
dc.contributor.author | Rodriguez Morato, Jose |
dc.contributor.author | Ramon, Jose M. |
dc.contributor.author | Perez Maña, Clara |
dc.contributor.author | Papaseit, Esther |
dc.contributor.author | Civit, Ester |
dc.contributor.author | Langohr, Klaus |
dc.contributor.author | Li Carbo, Marcel |
dc.contributor.author | De la Torre Fornell, Rafael |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa |
dc.date.accessioned | 2018-02-13T14:15:58Z |
dc.date.available | 2018-12-01T01:31:21Z |
dc.date.issued | 2017-05-30 |
dc.identifier.citation | Goday, A., Farré, M., Rodriguez, J., Ramon, J., Perez, C., Papaseit, E., Civit, E., Langohr, K., Li Carbo, M., De la Torre, R. Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism. "Obesity Surgery", 30 Maig 2017, vol. 27, núm. 12, p. 3194-3201. |
dc.identifier.issn | 1708-0428 |
dc.identifier.uri | http://hdl.handle.net/2117/114078 |
dc.description.abstract | The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). In the present prospective study, we studied 24 morbid obese patients before, at 4 weeks, and 6 months after having undergone sleeve gastrectomy (n = 10) or Roux-en-Y gastric bypass (n = 14). For comparative purposes, 28 healthy controls (14 normal weights and 14 overweights) were also included in the study. Paracetamol pharmacokinetics was altered in the obese participants leading to lower bioavailability. Bariatric surgery resulted in faster absorption and normalized pharmacokinetic parameters, prompting an increase in paracetamol bioavailability. No differences were found between surgical procedures. In the case of caffeine, the ratio paraxanthine/caffeine did not differ between morbid obese and healthy individuals. This ratio remained unmodified after surgery, indicating that the liver function (assessed by cytochrome P450 1A2 activity) was unaffected by obesity or bariatric surgery. Paracetamol pharmacokinetics and caffeine plasma levels are altered in severely obese patients. The two studied bariatric surgical techniques normalize paracetamol oral bioavailability without impairing the liver function (measured by cytochrome P450 1A2 activity). |
dc.format.extent | 8 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat |
dc.subject.lcsh | Combinatorial analysis |
dc.subject.lcsh | Combinatorial probabilities |
dc.subject.lcsh | Biomathematics |
dc.subject.other | Clinical trial |
dc.subject.other | Gastric bypass |
dc.subject.other | Sleeve gastrectomy |
dc.subject.other | Morbid obesity |
dc.subject.other | Metabolism paracetamol |
dc.subject.other | Caffeine. |
dc.title | Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism |
dc.type | Article |
dc.subject.lemac | Combinatòria |
dc.subject.lemac | Probabilitats |
dc.subject.lemac | Biomatemàtica |
dc.contributor.group | Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica |
dc.identifier.doi | 10.1007/s11695-017-2745-z |
dc.description.peerreviewed | Peer Reviewed |
dc.subject.ams | Classificació AMS::05 Combinatorics::05B Designs and configurations |
dc.subject.ams | Classificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability |
dc.subject.ams | Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general |
dc.relation.publisherversion | https://link.springer.com/article/10.1007%2Fs11695-017-2745-z |
dc.rights.access | Open Access |
local.identifier.drac | 21087394 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Goday, A.; Farré, M.; Rodriguez, J.; Ramon, J.; Perez, C.; Papaseit, E.; Civit, E.; Langohr, K.; Li Carbo, M.; De la Torre, R. |
local.citation.publicationName | Obesity Surgery |
local.citation.volume | 27 |
local.citation.number | 12 |
local.citation.startingPage | 3194 |
local.citation.endingPage | 3201 |
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