Influence of gap junction dynamics on the stability of reentrant waves in cardiac tissue
Document typeConference lecture
Rights accessOpen Access
Constant conductances are often assumed when model- ing cardiac tissue. However experimental evidences have shown that gap junctions (GJ) actually connect adjacent cardiac myocytes. These GJ are complex proteins of the connexin family (Cx40; Cx43; Cx45 are the most common in human). These GJ modify the conductances between cardiac cell through a dynamical process. The aim of this study is to develop a bidomain model of the cardiac tis- sue where the dynamics of the connexins is also included. In particular we will compare the differences associated with the use of a monodomain versus bidomain formula- tion in inducing intra-cellular conductance variations. We have found that the monodomain formulation gives con- ductance variations a factor four to five larger with respect to the bidomain formulation.
CitationHawks, C., Elorza, J., Echebarria, B., Rodriguez Cantalapiedra, I., Peñaranda, A., Bragard, J. Influence of gap junction dynamics on the stability of reentrant waves in cardiac tissue. A: "Computers in Cardiology". 2016, p. 437-440.