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dc.contributor.authorStanciuc, Ana Maria
dc.contributor.authorFlamant, Quentin
dc.contributor.authorBiotteau Deheuvels, Katia
dc.contributor.authorStoddart, Martin J.
dc.contributor.authorAnglada Gomila, Marcos Juan
dc.contributor.authorPorporati, Alessandro A.
dc.contributor.authorKuntz, Meinhard
dc.contributor.authorGremillard, Laurent
dc.contributor.authorAlini, Mauro
dc.contributor.authorPeroglio, Marianna
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.identifier.citationStanciuc, A., Flamant, Q., Biotteau, K., Stoddart, M., Anglada, M., Porporati, A., Kuntz, M., Gremillard, L., Alini, M., Peroglio, M. Human primary osteoblast behaviour on microrough zirconia-toughened alumina and on selectively etched microrough zirconia-toughened alumina. "Journal of the european ceramic society", 1 Març 2018, vol. 38, núm. 3, p. 927-937.
dc.description.abstractHip arthroplasty cementless acetabular components require excellent mechanical properties, biocompatibility, low friction and good osseointegration with surrounding bone tissue. Zirconia-toughened alumina (ZTA) fulfils these demands but requires combination with a rough metal shell for adequate osseointegration. Surface modifications of ZTA could allow a metal-free solution, thus preserving the bone stock for an eventual revision surgery. In this study, selective chemical etching proved to be an innovative method for the introduction of nano-features on micro-rough surfaces obtained by injection moulding. Results suggest that micro-roughness, fluorine enrichment and nano-porosity at the surface of ZTA play a synergistic role on human osteoblast (hOb) maturation. Among the tested groups, hydrofluoric acid etched “medium” roughness (Sa = 330 nm) ZTA showed the highest and/or earliest ALP expression at both the protein and gene level, while microroughness alone induced only minor effects on hOb maturation on ZTA.
dc.format.extent11 p.
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.otherHuman primary osteoblast
dc.subject.otherSelective chemical etching
dc.titleHuman primary osteoblast behaviour on microrough zirconia-toughened alumina and on selectively etched microrough zirconia-toughened alumina
dc.contributor.groupUniversitat Politècnica de Catalunya. CIEFMA - Centre d'Integritat Estructural, Micromecànica i Fiabilitat dels Materials
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - publisher's policy
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/289958/EU/BIOCERAMICS FOR BONE REPAIR/BIOBONE
local.citation.authorStanciuc, A.; Flamant, Q.; Biotteau, K.; Stoddart, M.; Anglada, M.; Porporati, A.; Kuntz, M.; Gremillard, L.; Alini, M.; Peroglio, M.
local.citation.publicationNameJournal of the european ceramic society

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