Human primary osteoblast behaviour on microrough zirconia-toughened alumina and on selectively etched microrough zirconia-toughened alumina
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Hip arthroplasty cementless acetabular components require excellent mechanical properties, biocompatibility, low friction and good osseointegration with surrounding bone tissue. Zirconia-toughened alumina (ZTA) fulfils these demands but requires combination with a rough metal shell for adequate osseointegration. Surface modifications of ZTA could allow a metal-free solution, thus preserving the bone stock for an eventual revision surgery. In this study, selective chemical etching proved to be an innovative method for the introduction of nano-features on micro-rough surfaces obtained by injection moulding. Results suggest that micro-roughness, fluorine enrichment and nano-porosity at the surface of ZTA play a synergistic role on human osteoblast (hOb) maturation. Among the tested groups, hydrofluoric acid etched “medium” roughness (Sa = 330 nm) ZTA showed the highest and/or earliest ALP expression at both the protein and gene level, while microroughness alone induced only minor effects on hOb maturation on ZTA.
CitationStanciuc, A., Flamant, Q., Biotteau, K., Stoddart, M., Anglada, M., Porporati, A., Kuntz, M., Gremillard, L., Alini, M., Peroglio, M. Human primary osteoblast behaviour on microrough zirconia-toughened alumina and on selectively etched microrough zirconia-toughened alumina. "Journal of the european ceramic society", 1 Març 2018, vol. 38, núm. 3, p. 927-937.