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Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue
dc.contributor.author | Waffenschmidt, T., Tobias |
dc.contributor.author | Cilla, Myriam |
dc.contributor.author | Sáez Viñas, Pablo |
dc.contributor.author | Pérez, Marta M. |
dc.contributor.author | Menzel, Andreas |
dc.contributor.author | Peña, E. |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental |
dc.date.accessioned | 2018-01-24T12:37:36Z |
dc.date.available | 2018-01-24T12:37:36Z |
dc.date.issued | 2016-08-16 |
dc.identifier.citation | Waffenschmidt, T., T., Cilla, M., Saez, P., Pérez, M., Menzel, A., Peña, E. Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue. "Journal of biomechanics", 16 Agost 2016, vol. 49, núm. 12, p. 2390-2397. |
dc.identifier.issn | 0021-9290 |
dc.identifier.uri | http://hdl.handle.net/2117/113143 |
dc.description.abstract | The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure–stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the mice aortas exhibit a saturation-type increase with respect to age. |
dc.format.extent | 8 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Investigació operativa::Programació matemàtica |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències |
dc.subject.lcsh | Biomathematics |
dc.subject.lcsh | Numerical analysis--Simulation methods |
dc.subject.lcsh | Combinatorial analysis |
dc.subject.other | Ageing |
dc.subject.other | Anisotropic biological tissues |
dc.subject.other | Thick-walled tube |
dc.subject.other | Parameter identification |
dc.title | Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue |
dc.type | Article |
dc.subject.lemac | Biomatemàtica |
dc.subject.lemac | Anàlisi numèrica |
dc.subject.lemac | Combinatòria |
dc.contributor.group | Universitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria |
dc.identifier.doi | 10.1016/j.jbiomech.2016.01.043 |
dc.description.peerreviewed | Peer Reviewed |
dc.subject.ams | Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general |
dc.subject.ams | Classificació AMS::65 Numerical analysis::65C Probabilistic methods, simulation and stochastic differential equations |
dc.subject.ams | Classificació AMS::05 Combinatorics::05E Algebraic combinatorics |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0021929016301269?via%3Dihub |
dc.rights.access | Open Access |
local.identifier.drac | 21706443 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Waffenschmidt T., T.; Cilla, M.; Saez, P.; Pérez, M.; Menzel, A.; Peña, E. |
local.citation.publicationName | Journal of biomechanics |
local.citation.volume | 49 |
local.citation.number | 12 |
local.citation.startingPage | 2390 |
local.citation.endingPage | 2397 |
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