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Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue

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10.1016/j.jbiomech.2016.01.043
 
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hdl:2117/113143

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Waffenschmidt, T., Tobias
Cilla, Myriam
Sáez Viñas, PabloMés informacióMés informacióMés informació
Pérez, Marta M.
Menzel, Andreas
Peña, E.
Document typeArticle
Defense date2016-08-16
Rights accessOpen Access
All rights reserved. This work is protected by the corresponding intellectual and industrial property rights. Without prejudice to any existing legal exemptions, reproduction, distribution, public communication or transformation of this work are prohibited without permission of the copyright holder
Abstract
The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure–stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the mice aortas exhibit a saturation-type increase with respect to age.
CitationWaffenschmidt, T., T., Cilla, M., Saez, P., Pérez, M., Menzel, A., Peña, E. Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue. "Journal of biomechanics", 16 Agost 2016, vol. 49, núm. 12, p. 2390-2397. 
URIhttp://hdl.handle.net/2117/113143
DOI10.1016/j.jbiomech.2016.01.043
ISSN0021-9290
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S0021929016301269?via%3Dihub
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  • Departament d'Enginyeria Civil i Ambiental - Articles de revista [2.501]
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