Collective excitability in a mesoscopic neuronal model of epileptic activity
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hdl:2117/113120
Tipus de documentArticle
Data publicació2018-01-12
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Abstract
At the mesoscopic scale, the brain can be understood as a collection of interacting neuronal oscillators, but the
extent to which its sustained activity is due to coupling among brain areas is still unclear. Herewe address this issue
in a simplified situation by examining the effect of coupling between two cortical columns described via Jansen-Rit
neural mass models. Our results show that coupling between the two neuronal populations gives rise to stochastic
initiations of sustained collective activity, which can be interpreted as epileptic events. For large enough coupling
strengths, termination of these events results mainly from the emergence of synchronization between the columns,
and thus it is controlled by coupling instead of noise. Stochastic triggering and noise-independent durations are
characteristic of excitable dynamics, and thus we interpret our results in terms of collective excitability.
CitacióJedynak, M., Pons, A. J., Garcia, J. Collective excitability in a mesoscopic neuronal model of epileptic activity. "Physical review E: statistical, nonlinear, and soft matter physics", 12 Gener 2018, vol. 97, núm. 1, p. 012204-1-012204-8.
ISSN1539-3755
Versió de l'editorhttps://journals.aps.org/pre/abstract/10.1103/PhysRevE.97.012204
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arXiv_Jedynak_Pons_Garcia-Ojalvo_1707.03812.pdf | 1,171Mb | Visualitza/Obre |