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Logic regression analysis of gene polymorphisms and HDL levels in a nationally representative sample of Iranian adolescents: The CASPIAN-III study
dc.contributor.author | Moghadasi, Mehri |
dc.contributor.author | Kelishadi, Roya |
dc.contributor.author | Marateb, Hamid Reza |
dc.date.accessioned | 2018-01-19T09:03:48Z |
dc.date.available | 2018-01-19T09:03:48Z |
dc.date.issued | 2017-01-01 |
dc.identifier.citation | Moghadasi, M., Kelishadi, R., Marateb, H.R. Logic regression analysis of gene polymorphisms and HDL levels in a nationally representative sample of Iranian adolescents: The CASPIAN-III study. "International Journal of Endocrinology and Metabolism", 1 Gener 2017, vol. 15, p. 1-8. |
dc.identifier.issn | 1726-9148 1726913X |
dc.identifier.uri | http://hdl.handle.net/2117/112959 |
dc.description.abstract | Background: To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents. Methods: This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine the main effects and interactions of polymorphisms related to HDL-C levels. Results: The rs708272 polymorphism was significantly related to HDL-C levels. Moreover, rs708272 increased HDL-C levels and had a protective effect on HDL-C. The interaction of rs2230808 and rs5880 polymorphisms as well as the interaction of rs320 and rs708272 polymorphisms were associated with lower HDL-C levels. Furthermore, the interaction of rs320 and rs1801177 polymorphisms was associated with lower HDL-C levels. Conclusions:We found that not only single SNPs, but also interactions of several SNPs affect HDL-C levels. Given the high prevalence of low HDL-C in Middle Eastern populations, further genetic studies are required for detailed analysis. |
dc.format.extent | 8 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Pediatria |
dc.subject.lcsh | Lipoproteins--genetics |
dc.subject.other | High-Density lipoprotein |
dc.subject.other | Logic regression |
dc.subject.other | Pediatrics |
dc.subject.other | Polymorphism |
dc.title | Logic regression analysis of gene polymorphisms and HDL levels in a nationally representative sample of Iranian adolescents: The CASPIAN-III study |
dc.type | Article |
dc.subject.lemac | Lipoproteïnes--Genètica |
dc.identifier.doi | 10.5812/ijem.14037 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://endometabol.com/en/articles/14037.html |
dc.rights.access | Open Access |
local.identifier.drac | 21589220 |
dc.description.version | Postprint (published version) |
local.citation.author | Moghadasi, M.; Kelishadi, R.; Marateb, H.R. |
local.citation.publicationName | International Journal of Endocrinology and Metabolism |
local.citation.volume | 15 |
local.citation.startingPage | 1 |
local.citation.endingPage | 8 |