Optimum morphology of gold nanorods for light-induced hyperthermia
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Inclou dades d'ús des de 2022
Cita com:
hdl:2117/112881
Tipus de documentArticle
Data publicació2017-12-26
EditorRoyal Society of Chemistry
Condicions d'accésAccés obert
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Owing to their unique chemical and physical properties, colloidal gold nanoparticles have
prompted a wide variety of biocompatible nano-agents for cancer imaging, diagnosis and
treatment. In this context, biofunctionalized gold nanorods (AuNRs) are promising candidates
for light-induced hyperthermia, to cause local and selective damage in malignant tissue. Yet, the
efficacy of AuNR-based hyperthermia is highly dependent on several experimental parameters;
in particular, the AuNR morphology strongly affects both physical and biological involved
processes. In the present work, we systematically study the influence of different structural
parameters like the AuNR aspect ratio, length and molecular weight on in vitro cytotoxicity,
cellular uptake and heat generation efficiency. Our results enable us to identify the optimum
AuNR morphology to be used for in vivo hyperthermia treatment.
CitacióMorales- Dalmau, J. [et al.]. Optimum morphology of gold nanorods for light-induced hyperthermia. "Nanoscale", 26 Desembre 2017.
ISSN2040-3364
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