Comparison of two discrimination indexes in the categorisation of continuous predictors in time-to-event studies

Barrio, Irantzu; Rodríguez-Álvarez, María Xosé; Meira-Machado, Luis; Esteban, Cristóbal; Arostegui, Inmaculada

dc.contributor.author	Barrio, Irantzu
dc.contributor.author	Rodríguez-Álvarez, María Xosé
dc.contributor.author	Meira-Machado, Luis
dc.contributor.author	Esteban, Cristóbal
dc.contributor.author	Arostegui, Inmaculada
dc.date.accessioned	2018-01-12T15:44:36Z
dc.date.available	2018-01-12T15:44:36Z
dc.date.issued	2017-06-21
dc.identifier.citation	Barrio, I. [et al.]. Comparison of two discrimination indexes in the categorisation of continuous predictors in time-to-event studies. "SORT", 21 Juny 2017, vol. 1, p. 73-92.
dc.identifier.issn	1696-2281
dc.identifier.uri	http://hdl.handle.net/2117/112753
dc.description.abstract	The Cox proportionalhazards model is the most widely used su rvival prediction model for analysing time-to-event data. To measure the discrimination ability of a survival model the concordance probability index is widely used. In this work we studied and compared the performance of two different estimators of the concordance probability when a continuous predictor variable is cate- gorised in a Cox proportional hazards regression model. In p articular, we compared the c-index and the concordance probability estimator. We evaluated th e empirical performance of both es- timators through simulations. To categorise the predictor variable we propose a methodology which considers the maximal discrimination attained for th e categorical variable. We applied this methodology to a cohort of patients with chronic obstructiv e pulmonary disease, in particular, we categorised the predictor variable forced expiratory volu me in one second in percentage
dc.format.extent	20 p.
dc.language.iso	eng
dc.publisher	Institut d'Estadística de Catalunya
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica
dc.subject.other	Categorisation
dc.subject.other	prediction models
dc.subject.other	cutpoint
dc.subject.other	Cox model
dc.title	Comparison of two discrimination indexes in the categorisation of continuous predictors in time-to-event studies
dc.type	Article
dc.description.peerreviewed	Peer Reviewed
dc.subject.ams	Classificació AMS::62 Statistics::62N Survival analysis and censored data
dc.subject.ams	Classificació AMS::62 Statistics::62P Applications
dc.rights.access	Open Access
upcommons.citation.published	true
upcommons.citation.publicationName	SORT
upcommons.citation.volume	1
upcommons.citation.startingPage	73
upcommons.citation.endingPage	92