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dc.contributor.authorBaldini, Nicola
dc.contributor.authorPerut, Francesca
dc.contributor.authorMontufar Jiménez, Edgar Benjamin
dc.contributor.authorCiapetti, Gabriela
dc.contributor.authorSantin, Matteo
dc.contributor.authorSalvage, J
dc.contributor.authorTraykova, Tania
dc.contributor.authorPlanell Estany, Josep Anton
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2011-01-31T15:07:34Z
dc.date.available2011-01-31T15:07:34Z
dc.date.created2010-12-10
dc.date.issued2010-12-10
dc.identifier.citationPerut, F. [et al.]. Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response. "Acta biomaterialia", 10 Desembre 2010.
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/2117/11240
dc.description.abstractDespite their known osteoconductivity, clinical use of calcium phosphate cements is limited both by their relatively slow rate of resorption and by rheological properties incompatible with injectability. Bone in-growth and material resorption have been improved by the development of porous calcium phosphate cements. However, injectable formulations have so far only been obtained through the addition of relatively toxic surfactants. The present work describes the response of osteoblasts to a novel injectable foamed bone cement based on a composite formulation including the bioactive foaming agents soybean and gelatine. The foaming properties of both defatted soybean and gelatine gels were exploited to develop a self-hardening soy/gelatine/hydroxyapatite composite foam able to retain porosity upon injection. After setting, the foamed paste produced a calcium-deficient hydroxyapatite scaffold, showing good injectability and cohesion as well as interconnected porosity after injection. The intrinsic bioactivity of soybean and gelatine was shown to favour osteoblast adhesion and growth. These findings suggest that injectable, porous and bioactive calcium phosphate cements can be produced for bone regeneration through minimally invasive surgery.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials::Metal·lúrgia
dc.subject.lcshMaterials science
dc.titleNovel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response
dc.typeArticle
dc.subject.lemacFosfat de calci
dc.subject.lemacBiomaterials
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.actbio.2010.12.012
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - publisher's policy
drac.iddocument4593469
dc.description.versionPostprint (published version)
dc.contributor.covenanteeIstituto Ortopedico Rizzoli
upcommons.citation.authorPerut, F.; Montufar, E.; Ciapetti, G.; Santin, M.; Salvage, J.; Traykova, T.; Planell, J.; Ginebra, M.; Baldini, N.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameActa biomaterialia


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Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain