Absolute quantification in dopaminergic neurotransmission SPET imaging using a Monte Carlo-based scatter correction and fully 3D reconstruction
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Tipus de documentArticle
Data publicació2005-09
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Abstract
Dopamine transporter (DAT) ligands have been developed for in vivo imaging of the dopaminergic system in SPECT. Although the visual analysis of SPECT images is, in general, suitable for
clinical assessment, the accurate quantification of the striatal uptake might increase the sensitivity of the technique and help in the early diagnosis, follow-up, and eventual treatment response of Parkinson’s disease (PD). This work is focused on assessment of the quantification of specific uptake of 99mTc-
DAT ligands when compensation for all degrading phenomena is performed. Methods: The SimSET Monte Carlo (MC) code was used to generate a set of SPECT projections of a numeric striatal phantom with different specific uptake ratios (SURs). An
absolute quantification method (AQM), which performs a MCbased scatter compensation and a fully 3-dimensional (3D) reconstruction, was implemented. The scatter estimate was included in the reconstruction algorithm. Results: The use of
attenuation, point-spread-function (PSF), and scatter corrections resulted in an improvement in the value of the SUR of 37% on average with respect to the reconstruction without corrections.
The magnitude of each improvement corresponded to 7% for the attenuation correction, 12% for the PSF correction using a 2-dimensional reconstruction algorithm and a further 11% for
the PSF correction using a 3D reconstruction algorithm, and 7% for the scatter correction. Conclusion: Our findings indicate that the PSF correction plays a major role in the quantification of striatal uptake in comparison with the attenuation correction and the scatter correction. The implemented method also provides
an absolute quantification procedure based on MC methods that do not depend on empiric approximations. The relative quantification results using the proposed AQM accounted for
96%–97% of the nominal SUR, whereas the limit achieved using only primary photons attained 98%–99%. The volumetric activity values obtained using the AQM converged toward the nominal values.
CitacióCot, A. [et al.]. Absolute quantification in dopaminergic neurotransmission SPET imaging using a Monte Carlo-based scatter correction and fully 3D reconstruction. "Journal of nuclear medicine", Setembre 2005, vol. 46, núm. 9, p. 1497-1504.
ISSN0161-5505
Versió de l'editorhttp://jnm.snmjournals.org/cgi/reprint/46/9/1497.pdf
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20050901_Journa ... ne_Vol. 46_No. 9_JNM05.pdf | 310,8Kb | Accés restringit |