Quantification of dopaminergic neurotransmission SPECT studies with I-123-labelled radioligands. A comparison between different imaging systems and data acquisition protocols using Monte Carlo simulation
Visualitza/Obre
crespo2008EurJNuclMedMolImaging35p1334-quantificationSPECT_I123.pdf (272,4Kb) (Accés restringit)
Sol·licita una còpia a l'autor
Què és aquest botó?
Aquest botó permet demanar una còpia d'un document restringit a l'autor. Es mostra quan:
- Disposem del correu electrònic de l'autor
- El document té una mida inferior a 20 Mb
- Es tracta d'un document d'accés restringit per decisió de l'autor o d'un document d'accés restringit per política de l'editorial
Cita com:
hdl:2117/11209
Tipus de documentArticle
Data publicació2008-07
Condicions d'accésAccés restringit per política de l'editorial
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Purpose 123I-labelled radioligands are commonly used for
single-photon emission computed tomography (SPECT)
imaging of the dopaminergic system to study the dopamine
transporter binding. The aim of this work was to compare
the quantitative capabilities of two different SPECT systems
through Monte Carlo (MC) simulation.
Methods The SimSET MC code was employed to generate
simulated projections of a numerical phantom for two
gamma cameras equipped with a parallel and a fan-beam
collimator, respectively. A fully 3D iterative reconstruction
algorithm was used to compensate for attenuation, the
spatially variant point spread function (PSF) and scatter. A
post-reconstruction partial volume effect (PVE) compensation
was also developed.
Results For both systems, the correction for all degradations
and PVE compensation resulted in recovery factors of the
theoretical specific uptake ratio (SUR) close to 100%. For a
SUR value of 4, the recovered SUR for the parallel imaging
system was 33% for a reconstruction without corrections
(OSEM), 45%for a reconstruction with attenuation correction
(OSEM-A), 56% for a 3D reconstruction with attenuation and
PSF corrections (OSEM-AP), 68% for OSEM-AP with
scatter correction (OSEM-APS) and 97% for OSEM-APS
plus PVE compensation (OSEM-APSV). For the fan-beam
imaging system, the recovered SUR was 41% without corrections, 55% for OSEM-A, 65% for OSEM-AP, 75% for
OSEM-APS and 102% for OSEM-APSV.
Conclusion Our findings indicate that the correction for
degradations increases the quantification accuracy, with
PVE compensation playing a major role in the SUR
quantification. The proposed methodology allows us to
reach similar SUR values for different SPECT systems,
thereby allowing a reliable standardisation in multicentric
studies.
CitacióCrespo, C. [et al.]. Quantification of dopaminergic neurotransmission SPECT studies with I-123-labelled radioligands. A comparison between different imaging systems and data acquisition protocols using Monte Carlo simulation. "European journal of nuclear medicine and molecular Imaging", Juliol 2008, vol. 35, núm. 7, p. 1334-1342.
ISSN1619-7070
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
crespo2008EurJN ... antificationSPECT_I123.pdf | 272,4Kb | Accés restringit |