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dc.contributor.authorKoullapis, P.
dc.contributor.authorKassinos, S.C.
dc.contributor.authorMuela Castro, Jordi
dc.contributor.authorPérez Segarra, Carlos David
dc.contributor.authorRigola Serrano, Joaquim
dc.contributor.authorLehmkuhl, Oriol
dc.contributor.authorCui, Y.
dc.contributor.authorSommerfeld, M.
dc.contributor.authorElcner, J.
dc.contributor.authorJicha, M.
dc.contributor.authorSaveljic, I.
dc.contributor.authorFilipovic, N.
dc.contributor.authorLizal, F.
dc.contributor.authorNicolaou, L.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Màquines i Motors Tèrmics
dc.identifier.citationKoullapis, P., Kassinos, S., Muela, J., Perez, C., Rigola, J., Lehmkuhl, O., Cui, Y., Sommerfeld, M., Elcner, J., Jicha, M., Saveljic, I., Filipovic, N., Lizal, F., Nicolaou, L. Regional aerosol deposition in the human airways: the SimInhale benchmark case and a critical assessment of in silico methods. "European journal of pharmaceutical sciences", 7 Setembre 2017, vol. 113, p.77-94.
dc.description© 2017. This version is made available under the CC-BY-NC-ND 4.0 license
dc.description.abstractRegional deposition effects are important in the pulmonary delivery of drugs intended for the topical treatment of respiratory ailments. They also play a critical role in the systemic delivery of drugs with limited lung bioavailability. In recent years, significant improvements in the quality of pulmonary imaging have taken place, however the resolution of current imaging modalities remains inadequate for quantifying regional deposition. Computational Fluid-Particle Dynamics (CFPD) can fill this gap by providing detailed information about regional deposition in the extrathoracic and conducting airways. It is therefore not surprising that the last 15. years have seen an exponential growth in the application of CFPD methods in this area. Survey of the recent literature however, reveals a wide variability in the range of modelling approaches used and in the assumptions made about important physical processes taking place during aerosol inhalation. The purpose of this work is to provide a concise critical review of the computational approaches used to date, and to present a benchmark case for validation of future studies in the upper airways. In the spirit of providing the wider community with a reference for quality assurance of CFPD studies, in vitro deposition measurements have been conducted in a human-based model of the upper airways, and several groups within MP1404 SimInhale have computed the same case using a variety of simulation and discretization approaches. Here, we report the results of this collaborative effort and provide a critical discussion of the performance of the various simulation methods. The benchmark case, in vitro deposition data and in silico results will be published online and made available to the wider community. Particle image velocimetry measurements of the flow, as well as additional numerical results from the community, will be appended to the online database as they become available in the future.
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut
dc.subject.lcshComputational fluid dynamics
dc.subject.lcshRespiratory organs
dc.subject.lcshAerosol therapy
dc.subject.otherBenchmark case
dc.subject.otherComputational fluid particle dynamics
dc.subject.otherInhaled drug delivery
dc.subject.otherRegional deposition
dc.subject.otherRespiratory airways
dc.titleRegional aerosol deposition in the human airways: the SimInhale benchmark case and a critical assessment of in silico methods
dc.subject.lemacDinàmica de fluids computacional
dc.subject.lemacAparell respiratori
dc.contributor.groupUniversitat Politècnica de Catalunya. CTTC - Centre Tecnològic de la Transferència de Calor
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorKoullapis, P.; Kassinos, S.; Muela, J.; Perez, C.; Rigola, J.; Lehmkuhl, O.; Cui, Y.; Sommerfeld, M.; Elcner, J.; Jicha, M.; Saveljic, I.; Filipovic, N.; Lizal, F.; Nicolaou, L.
upcommons.citation.publicationNameEuropean journal of pharmaceutical sciences

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Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain