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dc.contributor.authorGraffelman, Jan
dc.contributor.authorWeir, B.S.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.date.accessioned2017-11-22T10:07:59Z
dc.date.available2017-11-22T10:07:59Z
dc.date.issued2018-02-01
dc.identifier.citationGraffelman, J., Weir, B. On the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers. "Genetic epidemiology", 1 Gener 2017, p. 1-15.
dc.identifier.issn0741-0395
dc.identifier.urihttp://hdl.handle.net/2117/111053
dc.description.abstractStandard statistical tests for equality of allele frequencies in males and females and tests for Hardy-Weinberg equilibrium are tightly linked by their assumptions. Tests for equality of allele frequencies assume Hardy-Weinberg equilibrium, whereas the usual chi-square or exact test for Hardy-Weinberg equilibrium assume equality of allele frequencies in the sexes. In this paper, we propose ways to break this interdependence in assumptions of the two tests by proposing an omnibus exact test that can test both hypotheses jointly, as well as a likelihood ratio approach that permits these phenomena to be tested both jointly and separately. The tests are illustrated with data from the 1000 Genomes project.
dc.format.extent15 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada
dc.subject.lcshGenetic markers--Statistical methods
dc.subject.otherAkaike's information criterion
dc.subject.otherExact test
dc.subject.otherInbreeding coefficient
dc.subject.otherLikelihood ratio test
dc.subject.otherTernary diagram
dc.titleOn the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers
dc.typeArticle
dc.subject.lemacEstadística matemàtica
dc.subject.lemacMarcadors genètics -- Mètodes estadístics
dc.contributor.groupUniversitat Politècnica de Catalunya. COSDA-UPC - COmpositional and Spatial Data Analysis
dc.identifier.doi10.1002/gepi.22079
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/gepi.22079/abstract;jsessionid=1D494839D78796D3201A727E835E57C7.f02t01
dc.rights.accessOpen Access
drac.iddocument21604892
dc.description.versionPostprint (author's final draft)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/MINECO/MTM2015-65016-C2-2-R
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/2014SGR551
upcommons.citation.authorGraffelman, J., Weir, B.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameGenetic epidemiology
upcommons.citation.volume42
upcommons.citation.number1
upcommons.citation.startingPage34
upcommons.citation.endingPage48


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